Access to Conjugated Enynes via Allenyl Silver Formation/Cyclization/Decarboxylation Reaction Catalyzed by Silver Carbonate(I),Organic Letters

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Access to Conjugated Enynes via Allenyl Silver Formation/Cyclization/Decarboxylation Reaction Catalyzed by Silver Carbonate(I)
Organic Letters ( IF 4.9 ) Pub Date : 2022-08-03 , DOI: 10.1021/acs.orglett.2c02142
Bao Yu ₁ , Mohamed Selkti ₁ , Janick Ardisson ₁ , Marie-Isabelle Lannou ₁ , Geoffroy Sorin ₁

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Herein, we develop a novel and straightforward access to cyclic conjugated enynes catalyzed by silver carbonate/DBU from readily available substrates with good yields. The reaction is easy to set up, broad in scope, and can also be conducted in a one-pot fashion from easily accessible substrates through a sequence Michael addition reaction/cyclization. Based on our previous works, the mechanism proposed would involve an allenyl silver intermediate and decarboxylation reaction.

中文翻译：

碳酸银催化的烯丙基银形成/环化/脱羧反应获得共轭烯炔(I)

在此，我们开发了一种新颖且直接的方法，可从容易获得的底物以良好的收率获得由碳酸银/DBU 催化的环状共轭烯。该反应易于建立，范围广泛，并且还可以通过一系列迈克尔加成反应/环化从易于获得的底物以一锅方式进行。根据我们之前的工作，提出的机制将涉及烯基银中间体和脱羧反应。

更新日期：2022-08-03

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