Diet-induced inflammation in the anterior paraventricular thalamus induces compulsive sucrose-seeking,Nature Neuroscience

当前位置： X-MOL 学术 › Nat. Neurosci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Diet-induced inflammation in the anterior paraventricular thalamus induces compulsive sucrose-seeking
Nature Neuroscience ( IF 21.2 ) Pub Date : 2022-08-01 , DOI: 10.1038/s41593-022-01129-y
Jingjing Cheng _{1,

2,

3} , Xiaolin Ma _{1,

2} , Chunlu Li _{1,

4} , Rahim Ullah _{1,

5} , Xiaoyu Wang _{1,

2} , Jianmei Long _{1,

2} , Zhenxin Yuan _{1,

2} , Shuangshuang Liu ₆ , Junfen Fu ₅ , Zhong Chen ₇ , Yi Shen _{1,

8} , Yu-Dong Zhou _{1,

2,

8,

9}

Affiliation

Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, Zhejiang University School of Brain Science and Brain Medicine, Hangzhou, China.
Department of Ophthalmology of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Laboratory Medicine Center, Department of Transfusion Medicine, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, China.
Department of Psychology, School of Medical Humanitarians, Guizhou Medical University, Guiyang, China.
Department of Endocrinology, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Core Facilities, Zhejiang University School of Medicine, Hangzhou, China.
Department of Pharmacology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Zhejiang Laboratory for Systems & Precision Medicine, Zhejiang University Medical Center, Hangzhou, China.
Lingang Laboratory, Shanghai, China.

Overconsumption of palatable food may initiate neuroadaptive responses in brain reward circuitry that may contribute to eating disorders. Here we report that high-fat diet (HFD) consumption impedes threat-cue-induced suppression of sucrose-seeking in mice. This compulsive sucrose-seeking was due to enhanced cue-triggered neuronal activity in the anterior paraventricular thalamus (aPVT) resulting from HFD-induced microglia activation. Thus, metabolic inflammation in the aPVT produces an adaptive response to threat cues, leading to compulsive food-seeking.

中文翻译：

饮食诱导的前室旁丘脑炎症诱导强迫性蔗糖寻求

过度食用可口的食物可能会在大脑奖赏回路中引发神经适应性反应，这可能会导致饮食失调。在这里，我们报告高脂肪饮食 (HFD) 消费阻碍了威胁提示诱导的小鼠对蔗糖寻求的抑制。这种强迫性的蔗糖寻求是由于 HFD 诱导的小胶质细胞激活导致前室旁丘脑 (aPVT) 中线索触发的神经元活动增强。因此，aPVT 中的代谢性炎症会对威胁线索产生适应性反应，从而导致强迫性觅食。

更新日期：2022-08-02

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11