A straightforward approach to the synthesis of 3-bromoindoles via palladium-catalyzed oxidative C–H activation/annulation of N-alkylanilines with bromoalkynes has been described. This protocol features high atom economy, excellent chemo- and regioselectivities, and good functional group tolerance. Moreover, the resultant 3-bromoindoles can be transformed to various functionalized indole derivatives, which demonstrates the practicability of this method in organic synthesis.

中文翻译：

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N-烷基苯胺与溴炔烃的钯催化氧化 C-H 活化/环化：获得功能化的 3-溴吲哚

已经描述了通过钯催化的氧化 C-H 活化 / N-烷基苯胺与溴炔烃的环化来合成 3-溴吲哚的直接方法。该协议具有高原子经济性、优异的化学和区域选择性以及良好的官能团耐受性。此外，所得的3-溴吲哚可以转化为各种功能化的吲哚衍生物，证明了该方法在有机合成中的实用性。