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Voyage to minimal base editors
Nature Chemical Biology ( IF 12.9 ) Pub Date : 2022-08-01 , DOI: 10.1038/s41589-022-01101-8 Beomjong Song 1 , Sangsu Bae 2, 3
Nature Chemical Biology ( IF 12.9 ) Pub Date : 2022-08-01 , DOI: 10.1038/s41589-022-01101-8 Beomjong Song 1 , Sangsu Bae 2, 3
Affiliation
Transposon-associated transposase B (TnpB) is the putative ancestor of Cas nucleases. A TnpB-based adenine base editor has now been developed that is small enough to be loaded into a single AAV vector without compromising editing activity.
中文翻译:
极简碱基编辑之旅
转座子相关转座酶 B (TnpB) 是 Cas 核酸酶的假定祖先。现在已经开发出基于 TnpB 的腺嘌呤碱基编辑器,它足够小,可以加载到单个 AAV 载体中,而不会影响编辑活动。
更新日期:2022-08-02
中文翻译:
极简碱基编辑之旅
转座子相关转座酶 B (TnpB) 是 Cas 核酸酶的假定祖先。现在已经开发出基于 TnpB 的腺嘌呤碱基编辑器,它足够小,可以加载到单个 AAV 载体中,而不会影响编辑活动。