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Recognition in the Domain of Molecular Chirality: From Noncovalent Interactions to Separation of Enantiomers
Chemical Reviews ( IF 51.4 ) Pub Date : 2022-08-02 , DOI: 10.1021/acs.chemrev.1c00846
Paola Peluso 1 , Bezhan Chankvetadze 2
Affiliation  

It is not a coincidence that both chirality and noncovalent interactions are ubiquitous in nature and synthetic molecular systems. Noncovalent interactivity between chiral molecules underlies enantioselective recognition as a fundamental phenomenon regulating life and human activities. Thus, noncovalent interactions represent the narrative thread of a fascinating story which goes across several disciplines of medical, chemical, physical, biological, and other natural sciences. This review has been conceived with the awareness that a modern attitude toward molecular chirality and its consequences needs to be founded on multidisciplinary approaches to disclose the molecular basis of essential enantioselective phenomena in the domain of chemical, physical, and life sciences. With the primary aim of discussing this topic in an integrated way, a comprehensive pool of rational and systematic multidisciplinary information is provided, which concerns the fundamentals of chirality, a description of noncovalent interactions, and their implications in enantioselective processes occurring in different contexts. A specific focus is devoted to enantioselection in chromatography and electromigration techniques because of their unique feature as “multistep” processes. A second motivation for writing this review is to make a clear statement about the state of the art, the tools we have at our disposal, and what is still missing to fully understand the mechanisms underlying enantioselective recognition.

中文翻译:

分子手性领域的识别:从非共价相互作用到对映异构体的分离

手性和非共价相互作用在自然界和合成分子系统中普遍存在并非巧合。手性分子之间的非共价相互作用是对映选择性识别作为调节生命和人类活动的基本现象的基础。因此,非共价相互作用代表了一个引人入胜的故事的叙事线索,该故事跨越了医学、化学、物理、生物和其他自然科学的多个学科。这篇综述的构思是意识到对分子手性及其后果的现代态度需要建立在多学科方法的基础上,以揭示化学、物理和生命科学领域基本对映选择性现象的分子基础。以综合方式讨论这个话题为主要目的,提供了一个全面的理性和系统的多学科信息库,涉及手性的基本原理、非共价相互作用的描述以及它们在不同情况下发生的对映选择性过程中的影响。特别关注色谱和电迁移技术中的对映体选择,因为它们具有“多步”过程的独特特征。撰写这篇评论的第二个动机是明确说明现有技术、我们可以使用的工具,以及仍然缺少什么来充分理解对映选择性识别的机制。以及它们在不同情况下发生的对映选择性过程中的影响。特别关注色谱和电迁移技术中的对映体选择,因为它们具有“多步”过程的独特特征。撰写这篇评论的第二个动机是明确说明现有技术、我们可以使用的工具,以及仍然缺少什么来充分理解对映选择性识别的机制。以及它们在不同情况下发生的对映选择性过程中的影响。特别关注色谱和电迁移技术中的对映体选择,因为它们具有“多步”过程的独特特征。撰写这篇评论的第二个动机是明确说明现有技术、我们可以使用的工具,以及仍然缺少什么来充分理解对映选择性识别的机制。
更新日期:2022-08-02
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