An arrayed host:guest fluorescence sensor system can discriminate DNA G-quadruplex structures that differ only in the presence of single oxidation or methylation modification in the guanine base. These small modifications make subtle changes to G4 folding that are often not detectable by CD but induce differential fluorescence responses in the array. The sensing is functional in diluted serum and is capable of distinguishing individual modifications in DNA mixtures, providing a powerful method of detecting folding changes caused by DNA damage.

中文翻译：

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用优化的宿主感知非规范折叠 DNA 中的碱基修饰：客体感知阵列

排列的宿主：客体荧光传感器系统可以区分仅在鸟嘌呤碱基中存在单一氧化或甲基化修饰时不同的 DNA G-四链体结构。这些小的修改对 G4 折叠进行了细微的更改，这些更改通常无法被 CD 检测到，但会在阵列中引起不同的荧光响应。传感在稀释的血清中起作用，能够区分 DNA 混合物中的个体修饰，提供了一种检测由 DNA 损伤引起的折叠变化的强大方法。