Abstract: Acute kidney injury (AKI) is a clinical syndrome in which kidney function declines sharply due to various reasons. Although the morbidity and mortality of AKI are high, the mechanism of occurrence and development of AKI has not been fully elucidated, and precise prevention and treatment measures are lacking. Epigenetics is a branch of genetics that provides a new perspective to explore the pathophysiology of AKI and renal repair. A large amount of literature shows that the methylation mechanism of H3 in histones is closely related to the development of kidney diseases. The sorting out of histone H3 methylation mechanism in AKI and kidney repair can help understand the pathophysiological process of the disease more deeply. It may also provide new ideas for diagnosing and treating of the disease.

Keywords: kidney, Acute kidney injury, histone methylation, epigenetic


中文翻译：

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组蛋白 H3 甲基化在急性肾损伤中的作用

【摘要】：急性肾损伤(AKI)是由于各种原因导致肾功能急剧下降的临床综合征。虽然 AKI 的发病率和死亡率都很高，但 AKI 的发生发展机制尚未完全阐明，缺乏精准的防治措施。表观遗传学是遗传学的一个分支，它为探索 AKI 的病理生理学和肾脏修复提供了新的视角。大量文献表明，组蛋白中H3的甲基化机制与肾脏疾病的发生发展密切相关。梳理AKI和肾脏修复中组蛋白H3甲基化机制有助于更深入地了解疾病的病理生理过程。它还可能为疾病的诊断和治疗提供新的思路。

关键词：肾脏，急性肾损伤，组蛋白甲基化，表观遗传