Although photodynamic therapy (PDT) has attracted great interest, the photosensitizers in clinical had weak inhibition on metastasis and invasion of cancers. Additionally the immune response induced by PDT was insufficient to eradicate cancer. Herein, indoximod, an inhibitor of indoleamine 2,3-dioxygenase (IDO), is introduced to concatenate with zinc phthalocyanines (ZnPc) for effectively overcoming above inadequacy. Due to indoximod moiety, photosensitizer 1-MT-Pc can obtain enhanced intracellular uptake and high reactive oxygen species (ROS) generation. More impressively, 1-MT-Pc can achieve remarkable photocytotoxicity towards TNBC cells and negligible damage to normal cells. Meanwhile, 1-MT-Pc effectively inhibits metastasis and invasion of TNBC cells. Importantly, 1-MT-Pc exhibit elevated inhibitory effect on 4T1 tumor by enhanced PDT and immunotherapy.

尽管光动力疗法（PDT）引起了人们的极大兴趣，但临床上的光敏剂对癌症的转移和侵袭的抑制作用较弱。此外，PDT 诱导的免疫反应不足以根除癌症。在此，indoximod 是一种吲哚胺 2,3-双加氧酶 (IDO) 的抑制剂，被引入与锌酞菁 (ZnPc) 连接，以有效克服上述不足。由于 indoximod 部分，光敏剂1-MT-Pc可以获得增强的细胞内摄取和高活性氧 (ROS) 生成。更令人印象深刻的是，1-MT-Pc可以对 TNBC 细胞产生显着的光细胞毒性，而对正常细胞的损伤可以忽略不计。同时，1-MT-Pc有效抑制TNBC细胞的转移和侵袭。重要的是，1-MT-Pc通过增强的 PDT 和免疫疗法对 4T1 肿瘤表现出更高的抑制作用。