Purpose

Microemulsions (MEs) are homogeneous, optically clear and thermodynamically stable systems intended to increase the bioavaibility, solubility, and entrapment of drugs. In this study, a new system of oil-in-water MEs was formulated with Fusidic acid as a drug. MEs were composed of Isopropyl myristate, non-ionic surfactants tween 80, 1-propanol and water.

Methods

The optimum weight ratios of components and MEs areas were determined by pseudoternary phase diagram. The prepared microemulsions were evaluated regarding their stability, pH, refractive index, conductivity, viscosity, particle size, zeta potential, surface tension and partition coefficient.

Results

These parameters suggested that the optimized MEs were stable and optically clear.

Conclusion

This study reveals that the product can be used for ocular treatment.

中文翻译：

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基于假三元相图的夫西地酸微乳液：开发、表征和评价

目的

微乳液 (ME) 是一种均质、光学透明和热力学稳定的系统，旨在提高药物的生物利用度、溶解度和截留性。在这项研究中，以夫西地酸为药物配制了一种新的水包油微系统。ME由肉豆蔻酸异丙酯、吐温80、1-丙醇和水的非离子表面活性剂组成。

方法

通过伪三元相图确定了组分和MEs面积的最佳重量比。对制备的微乳液的稳定性、pH、折射率、电导率、粘度、粒度、zeta电位、表面张力和分配系数进行了评价。

结果

这些参数表明优化后的 ME 稳定且光学清晰。

结论

该研究表明该产品可用于眼部治疗。