How the surface chemical properties of nanoceria are related to its enzyme-like, antiviral and degradation activity,Environmental Science: Nano

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How the surface chemical properties of nanoceria are related to its enzyme-like, antiviral and degradation activity
Environmental Science: Nano ( IF 5.8 ) Pub Date : 2022-08-01 , DOI: 10.1039/d2en00173j
Jiří Henych _{1,

2} , Martin Šťastný ₁ , Jakub Ederer ₂ , Zuzana Němečková ₁ , Aleksandra Pogorzelska ₃ , Jakub Tolasz _{1,

2} , Martin Kormunda ₄ , Petr Ryšánek ₄ , Barbara Bażanów ₃ , Dominika Stygar ₅ , Karel Mazanec ₆ , Pavel Janoš ₂

Affiliation

Five different water-based precipitation methods have been used to prepare nanoceria with significantly different redox and acid/base properties, which have been described in detail by a number of analytical methods. Differences in particle size, morphology, porosity, but especially in defect structure and in the surface chemical composition of nanoceria had a crucial impact on their reactivity in several environmentally and biologically oriented model reactions. Ceria-catalyzed hydrolysis of two phosphodiester biomolecules (p-NPPC and p-NP-TMP) revealed high phospholipase C and D mimetic activity of all tested materials. On the other hand, the efficiency in degradation of toxic organophosphates (methyl parathion/oxon, agent VX, GD) is highly dependent on the solvent used (water or acetonitrile). Water slows down the degradation rate, but has a strikingly different effect on each ceria sample, which is related to the ceria surface structure and its interaction with the model compound and/or water. Two materials with a significant number of defects and oxygen-containing surface groups also showed highly virucidal properties against enveloped (adenovirus 5) and non-enveloped (human herpes simplex) viruses while having very low cytotoxicity.

中文翻译：

纳米瓷的表面化学性质与其酶样、抗病毒和降解活性有何关系

五种不同的水基沉淀方法已用于制备具有显着不同氧化还原和酸/碱性质的纳米氧化铈，已通过多种分析方法对其进行了详细描述。颗粒大小、形态、孔隙率的差异，尤其是纳米氧化铈的缺陷结构和表面化学成分的差异，对其在几种环境和生物导向模型反应中的反应性产生了至关重要的影响。二氧化铈催化的两种磷酸二酯生物分子（p -NPPC 和p-NP-TMP) 揭示了所有测试材料的高磷脂酶 C 和 D 模拟活性。另一方面，降解有毒有机磷酸盐（甲基对硫磷/氧磷、试剂 VX、GD）的效率高度依赖于所使用的溶剂（水或乙腈）。水减缓了降解速度，但对每个二氧化铈样品的影响却截然不同，这与二氧化铈表面结构及其与模型化合物和/或水的相互作用有关。两种具有大量缺陷和含氧表面基团的材料也表现出对包膜病毒（腺病毒 5）和非包膜病毒（人类单纯疱疹病毒）的高度杀病毒特性，同时具有非常低的细胞毒性。

更新日期：2022-08-04

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