A three-component difunctionalization of N-alkenyl amides via organophotoredox radical-polar crossover,Chemical Communications

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A three-component difunctionalization of N-alkenyl amides via organophotoredox radical-polar crossover
Chemical Communications ( IF 4.3 ) Pub Date : 2022-08-01 , DOI: 10.1039/d2cc04101d
Roshan K Dhungana ₁ , Albert Granados ₁ , Mohammed Sharique ₁ , Jadab Majhi ₁ , Gary A Molander ₁

Affiliation

Herein, we report a three-component organophotoredox coupling of N-alkenyl amides with α-bromocarbonyls and various nucleophiles. This transition metal-free difunctionalization protocol installs sequential C–C and C–Y (Y = S/O/N) bonds in alkenes. This reaction works with terminal and internal alkenes containing both cyclic and acyclic amides via radical-polar crossover.

中文翻译：

通过有机光氧化还原自由基-极性交叉实现 N-烯基酰胺的三组分双官能化

在此，我们报道了N-烯基酰胺与 α-溴羰基和各种亲核试剂的三组分有机光氧化还原偶联。这种无过渡金属的双官能化方案在烯烃中安装了连续的 C-C 和 C-Y (Y = S/O/N) 键。该反应通过自由基-极性交叉作用于含有环状和无环酰胺的末端和内部烯烃。

更新日期：2022-08-05

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