PFKFB4 is dysregulated in varying tumors and has the biological function of regulating tumor progression. However, its biological function in cervical cancer is poorly understood. We obtained the upstream regulatory gene (miR-195-5p) of PFKFB4 through bioinformatics analysis. Then, experiments were introduced to measure expression and targeting relationship of miR-195-5p and PFKFB4 in cervical cancer cells, in order to evaluate their influence on proliferation, migration, invasion and angiogenesis of cervical cancer cells. As expressed in results, PFKFB4 was abnormally increased and boosted malignant progression of cervical cancer cells. Besides, miR-195-5p was markedly decreased and restrained PFKFB4 in cervical cancer. While tumor-suppressive effect of miR-195-5p was partially restored by overexpressing PFKFB4, indicating that miR-195-5p and PFKFB4 may be new therapeutic targets for cervical cancer patients.

PFKFB4 在不同的肿瘤中失调，具有调节肿瘤进展的生物学功能。然而，人们对其在宫颈癌中的生物学功能知之甚少。我们通过生物信息学分析获得了PFKFB4的上游调控基因（miR-195-5p）。然后，通过实验测量miR-195-5p和PFKFB4在宫颈癌细胞中的表达和靶向关系，以评估它们对宫颈癌细胞增殖、迁移、侵袭和血管生成的影响。结果表明，PFKFB4异常升高，促进了宫颈癌细胞的恶性进展。此外，miR-195-5p在宫颈癌中显着降低并抑制PFKFB4。虽然过表达 PFKFB4 部分恢复了 miR-195-5p 的肿瘤抑制作用，