Copper (II) complexes (3a-i) with (16E)-N-(2-phenylquinolin-4(1H)-ylidine)-2-(phenylselanyl)pyridine-3-amine ligands have been synthesized. They have been characterised by various spectroscopic studies. In-vitro cytotoxic potential has been determined, with significant cytotoxicity against MCF-7 cell line. The copper complexes interact with the calf thymus, (CT-DNA), according to absorption spectra and viscosity measurements. In addition, the copper complexes have been tested for their antimicrobial activity against three Gram-negative bacteria; Proteus vulgaris, Klebsiella pneumoniae, and Shigella flexneri, three Gram-positive bacteria; Staphylococcus aureus, Staphylococcus epidermidis, and Bacillus subtilis, and three fungi; Aspergillus fumigatus, Aspergillus clavatus and Candida albicans. The ligand's acetylcholinesterase (AChE) inhibiting function has been investigated in order to determine the ligand's efficacy in the treatment of neurodegenerative disorders. When compared to standard Rivastigmine and Galantamine, the synthesised ligand 2c show selective inhibition (AChE and BuChE) with IC50 values of 0.19 and 3.03 μM. The egg albumin method is used to test the anti-inflammatory efficiency and α-glucosidase inhibitory activities of copper chelates are tested.

中文翻译：

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铜配合物与苯基硒基配体的抗菌、细胞毒性、DNA结合、胆碱酯酶研究的体外评价

已经合成了具有 (16E)-N-(2-phenylquinolin-4(1H)-ylidine)-2-(phenylselanyl)pyridine-3-amine 配体的铜 (II) 配合物 (3a-i)。它们已通过各种光谱研究进行了表征。已确定体外细胞毒性潜力，对 MCF-7 细胞系具有显着的细胞毒性。根据吸收光谱和粘度测量，铜络合物与小牛胸腺 (CT-DNA) 相互作用。此外，铜配合物已针对三种革兰氏阴性菌进行了抗菌活性测试。普通变形杆菌、肺炎克雷伯菌和福氏志贺菌，三种革兰氏阳性菌；金黄色葡萄球菌、表皮葡萄球菌、枯草芽孢杆菌和三种真菌；烟曲霉、棒曲霉和白色念珠菌。配体' 已经研究了 s 乙酰胆碱酯酶 (AChE) 抑制功能，以确定配体在治疗神经退行性疾病中的功效。与标准的卡巴拉汀和加兰他敏相比，合成的配体 2c 显示出选择性抑制作用（AChE 和 BuChE），IC50 值为 0.19 和 3.03 μM。采用卵白蛋白法检测抗炎效果，检测铜螯合物的α-葡萄糖苷酶抑制活性。