In this study a microparticular drug delivery system containing tamarind shell and chitosan has been developed to realize the controlled release of methylprednisolone sodium succinate an important corticosteroid. Drug-loaded tamarind shells are coated with chitosan for a pH-controlled release. The release kinetics of the system have been examined in detail at three different pH ranges (3, 5 and 7.4). In our pH sensitive release systems a slow release up to 39.02%±0.81 at pH=7.4 at 72 hours. But we see that there is a faster release at 70.58±1.73% at pH=5 and 96.68±1.70% at pH=3 in 72 hours. Rapid release in acidic media depends on the solubility of the chitosan structure in acidic environments. It is believed that the pH sensitive carrier system obtained within the scope of the study will have a high potential for use in many biomedical application areas (wound surface application, etc.).

中文翻译：

---

从罗望子壳制造基于壳聚糖的药物释放系统，用于长期有效的甲基强的松龙琥珀酸钠释放

本研究开发了一种含有罗望子壳和壳聚糖的微粒给药系统，以实现重要皮质类固醇甲基强的松龙琥珀酸钠的控释。载药罗望子壳涂有壳聚糖，以控制 pH 值的释放。系统的释放动力学已在三个不同的 pH 范围（3、5 和 7.4）下进行了详细检查。在我们的 pH 敏感释放系统中，在 72 小时时在 pH=7.4 时缓慢释放高达 39.02%±0.81。但我们看到，在 72 小时内，在 pH=5 和 96.68±1.70% 时，pH=5 和 96.68±1.70% 的释放速度更快。在酸性介质中的快速释放取决于壳聚糖结构在酸性环境中的溶解度。