Glaucoma is a leading cause of irreversible blindness. The use of topical eye drops to reduce intraocular pressure remains the mainstay treatment. These eye drops frequently contain preservatives designed to ensure sterility of the compound. A growing number of clinical and experimental studies report the detrimental effects of not only these preservatives but also the active pharmaceutical compounds on the ocular surface, with resultant tear film instability and dry eye disease. Herein, we critically appraise the published literature exploring the effects of preservatives and pharmaceutical compounds on the ocular surface.

中文翻译：

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局部青光眼药物——对眼表的临床意义

青光眼是不可逆失明的主要原因。使用局部滴眼液来降低眼内压仍然是主要的治疗方法。这些滴眼液通常含有防腐剂，旨在确保化合物无菌。越来越多的临床和实验研究报告了不仅这些防腐剂而且活性药物化合物对眼表的不利影响，导致泪膜不稳定和干眼病。在此，我们批判性地评价已发表的文献，探索防腐剂和药物化合物对眼表的影响。