Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2022-07-30 , DOI: 10.1016/j.addr.2022.114468 Bishal Raj Adhikari 1 , Keith C Gordon 2 , Shyamal C Das 1
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High dose inhaled powders have received increased attention for treating lung infections. These powders can be prepared using techniques such as spray drying, spray-freeze drying, crystallization, and milling. The selected preparation technique is known to influence the solid state of the powders, which in turn can potentially modulate aerosolization and aerosolization stability. This review focuses on how and to what extent the change in solid state of high dose powders can influence aerosolization. It also discusses the commonly used solid state characterization techniques and the application of potential strategies to improve the physical and chemical stability of the amorphous powders for high dose delivery.
中文翻译：
可吸入高剂量粉末的固态
高剂量吸入粉末在治疗肺部感染方面受到越来越多的关注。可以使用喷雾干燥、喷雾冷冻干燥、结晶和研磨等技术制备这些粉末。已知所选的制备技术会影响粉末的固态，进而可能调节雾化和雾化稳定性。这篇综述的重点是高剂量粉末的固态变化如何以及在多大程度上影响雾化。它还讨论了常用的固态表征技术和潜在策略的应用，以提高无定形粉末的物理和化学稳定性以用于高剂量输送。
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