Gliomas are the deadliest of all primary brain tumors, and they constitute a serious global health problem. MicroRNAs (miRNAs) are gene expression regulators associated with glioma pathogenesis. Thus, miRNAs represent potential therapeutic agents for treating gliomas. However, miRNAs have not been established as part of the regular clinical armamentarium. This systemic review evaluates current molecular and pre-clinical studies with the aim of defining the most appealing supramolecular platform for administering therapeutic miRNA to patients with gliomas. An integrated analysis suggested that cationic lipid nanoparticles, functionalized with octa-arginine peptides, represent a potentially specific, practical, non-invasive intervention for treating gliomas. This supramolecular platform allows loading both hydrophilic (miRNA) and hydrophobic (anti-tumor drugs, like temozolomide) molecules. This systemic review is the first to describe miRNA delivery systems targeted to gliomas that integrate several types of molecules as active ingredients. Further experimental validation is warranted to confirm the practical value of miRNA delivery systems.

胶质瘤是所有原发性脑肿瘤中最致命的，它们构成了严重的全球健康问题。MicroRNAs (miRNAs) 是与胶质瘤发病机制相关的基因表达调节因子。因此，miRNA 代表了治疗神经胶质瘤的潜在治疗剂。然而，miRNA 尚未成为常规临床设备的一部分。该系统评价评估了当前的分子和临床前研究，旨在确定最吸引人的超分子平台，用于向胶质瘤患者施用治疗性 miRNA。一项综合分析表明，用八精氨酸肽功能化的阳离子脂质纳米颗粒代表了治疗神经胶质瘤的潜在特异性、实用、非侵入性干预措施。这种超分子平台允许加载亲水 (miRNA) 和疏水（抗肿瘤药物，如替莫唑胺）分子。该系统综述首次描述了针对胶质瘤的 miRNA 递送系统，该系统整合了几种类型的分子作为活性成分。需要进一步的实验验证来确认 miRNA 传递系统的实用价值。