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Dark genome, bright ideas: Recent approaches to harness transposable elements in immunotherapies
Cancer Cell ( IF 48.8 ) Pub Date : 2022-07-30 , DOI: 10.1016/j.ccell.2022.07.003 Ashley Reid Cahn 1 , Nina Bhardwaj 2 , Nicolas Vabret 1
中文翻译:
黑暗基因组,聪明的想法:在免疫疗法中利用转座元件的最新方法
更新日期:2022-07-30
Cancer Cell ( IF 48.8 ) Pub Date : 2022-07-30 , DOI: 10.1016/j.ccell.2022.07.003 Ashley Reid Cahn 1 , Nina Bhardwaj 2 , Nicolas Vabret 1
Affiliation
Transposable elements (TEs), which make up almost half of the human genome, often display altered expression in cancers. Here, we review recent progress in elucidating the role of TEs as mediators of immune responses in cancer and discuss how novel therapeutic strategies can harness TE immunogenicity for cancer immunotherapy.
中文翻译:
黑暗基因组,聪明的想法:在免疫疗法中利用转座元件的最新方法
转座元件(TE)几乎占人类基因组的一半,通常在癌症中表现出改变的表达。在这里,我们回顾了阐明 TE 作为癌症免疫反应介质的作用的最新进展,并讨论了新的治疗策略如何利用 TE 免疫原性进行癌症免疫治疗。