STUDY QUESTION Are donor-conceived people (DCP) willing to utilize donor gametes themselves if unable to conceive spontaneously? SUMMARY ANSWER The majority of DCP would consider or are undecided about utilizing donor gametes and those who would consider the utilization are more likely to have been told about their donor-conceived origins at a young age by a family member and have overall positive experiences as a DCP. WHAT IS KNOWN ALREADY DCP view their donor conception as an important part of their self-identity and many desire contact with genetically related individuals. Additionally, many believe that sperm donation should only be practiced if identifying information on the donor is provided. STUDY DESIGN, SIZE, DURATION This was a cross-sectional study using a Web-based survey that was disseminated from 6 March to 15 August 2021. A total of 528 participants completed the questionnaire. PARTICIPANTS/MATERIALS, SETTING, METHODS The researcher-created survey was sent to registered users of the Donor Sibling Registry (DSR) who were conceived via donor-assisted reproduction and were 18 years of age or older. The survey was optional and anonymous, and the main outcome measure was the willingness to use donated gametes if unable to spontaneously conceive. MAIN RESULTS AND THE ROLE OF CHANCE Of the 528 participants who completed the survey, 40.2% (212/528) have or would consider using donor gametes themselves if unable to conceive spontaneously and 24.6% (130/528) were undecided. Those who had used or were undecided about the utilization were significantly younger (26 years vs. 31 years, P < 0.001) and less likely to be married (32.7% vs. 47.3%, P < 0.001) than those who would not consider using donor gametes. They were also less likely to self-identify as female (78.9% vs. 86.6%, P = 0.03) but had no difference in sexual orientation (P = 0.13). Additionally, they were more likely to have known about their donor-conceived origins for more years (18 (0–50) vs. 11 (0–61), P = 0.004), be informed by a family member (75.5% vs. 65.6%, P = 0.001) and have overall positive feelings about being conceived using a donor (93.0% vs. 52.5%, P < 0.001). LIMITATIONS, REASONS FOR CAUTION A major limitation is that DSR participants may not be representative of all DCP. Additionally, analyzing the DCP who stated that they were undecided about using donor gametes into the ‘would consider’ group may be overestimating the openness to utilization in this group. WIDER IMPLICATIONS OF THE FINDINGS The findings from this study give new insight for health care workers to further counsel patients who are considering using third-party reproduction by providing reassurance that the majority of their future children would consider similar means, if needed, to achieve their family-building goals. STUDY FUNDING/COMPETING INTEREST(S) Funding for this study was received from the Department of Obstetrics and Gynecology Division of Reproductive Endocrinology and Infertility, University of Colorado. All authors declare that there are no conflicts of interest to disclose. TRIAL REGISTRATION NUMBER N/A.

中文翻译：

---

受捐者受孕的人愿意自己使用捐献者吗？通过捐赠者辅助生殖受孕的个体的见解

研究问题 如果无法自然受孕，捐赠者受孕者 (DCP) 是否愿意自己利用捐赠者配子？总结性回答 大多数 DCP 会考虑或尚未决定是否使用供体配子，而那些考虑使用供体配子的人更有可能在年轻时就被家庭成员告知其由供体受孕的起源，并且总体上具有作为配子的积极经验。 DCP。已知情况 DCP 将他们的捐赠者概念视为他们自我认同的重要组成部分，并且许多人希望与遗传相关的人接触。此外，许多人认为，只有提供了捐赠者的身份信息，才能进行精子捐赠。研究设计、规模、持续时间 这是一项横断面研究，使用了 2021 年 3 月 6 日至 8 月 15 日发布的基于网络的调查。共有 528 名参与者完成了问卷调查。参与者/材料、设置、方法 研究人员创建的调查被发送给通过捐赠者辅助生殖受孕且年龄在 18 岁或以上的捐赠者兄弟姐妹登记处 (DSR) 的注册用户。该调查是可选的和匿名的，主要结果衡量标准是如果无法自然受孕，是否愿意使用捐赠的配子。主要结果和机会的作用 在完成调查的 528 名参与者中，40.2% (212/528) 如果无法自然受孕，40.2% (212/528) 已经或将考虑自己使用供体配子，24.6% (130/528) 未决定。那些使用过或尚未决定使用的人明显更年轻（26 岁对 31 岁，P < 0.001），结婚的可能性更小（32.7% 对 47.3%，P < 0。001）比那些不会考虑使用供体配子的人。他们也不太可能自我认同为女性（78.9% 对 86.6%，P = 0.03），但在性取向方面没有差异（P = 0.13）。此外，他们更有可能知道其捐赠者受孕的起源多年（18（0-50）对 11（0-61），P = 0.004），由家庭成员告知（75.5% 对65.6%，P = 0.001）并且对使用捐赠者受孕有总体积极的感觉（93.0% 对 52.5%，P < 0.001）。限制，谨慎的原因 一个主要限制是 DSR 参与者可能不能代表所有 DCP。此外，分析表示他们尚未决定将供体配子纳入“将考虑”组的 DCP 可能高估了该组的使用开放性。研究结果的更广泛意义 这项研究的结果为卫生保健工作者提供了新的见解，可以通过确保他们未来的大多数孩子在需要时会考虑类似的方式来实现他们家庭建设目标。研究资金/竞争利益 本研究的资金来自科罗拉多大学生殖内分泌和不孕症妇产科系。所有作者均声明不存在要披露的利益冲突。试用注册号 不适用。