Regulation of NETosis and Inflammation by Cyclophilin D in Myeloperoxidase-Positive Antineutrophil Cytoplasmic Antibody–Associated Vasculitis,Arthritis & Rheumatology

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Regulation of NETosis and Inflammation by Cyclophilin D in Myeloperoxidase-Positive Antineutrophil Cytoplasmic Antibody–Associated Vasculitis
Arthritis & Rheumatology ( IF 11.4 ) Pub Date : 2022-07-29 , DOI: 10.1002/art.42314
Takashi Kudo ₁ , Daigo Nakazawa ₁ , Kanako Watanabe-Kusunoki ₁ , Masatoshi Kanda ₂ , Satoka Shiratori-Aso ₁ , Nobuya Abe ₃ , Saori Nishio ₁ , Jun-Ichiro Koga ₄ , Sari Iwasaki ₅ , Takahiro Tsuji ₅ , Yuichiro Fukasawa ₅ , Miwako Yamasaki ₆ , Masahiko Watanabe ₆ , Sakiko Masuda ₇ , Utano Tomaru ₈ , Masaaki Murakami ₉ , Yasuaki Aratani ₁₀ , Akihiro Ishizu ₇ , Tatsuya Atsumi ₁

Affiliation

Department of Rheumatology, Endocrinology, and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Department of Rheumatology and Clinical Immunology, Sapporo Medical University, Sapporo, Japan.
Department of Rheumatology, Endocrinology, and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, and Division of Molecular Psychoimmunology, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Department of Cardiovascular Medicine, Kyushu University, Graduate School of Medical Sciences, Fukuoka, Japan.
Department of Pathology, Sapporo City General Hospital, Sapporo, Japan.
Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.
Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Division of Molecular Psychoimmunology, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Graduate School of Nanobioscience, Yokohama City University, Yokohama, Japan.

Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) is pathologically characterized by focal fibrinoid necrosis, in which ANCA-mediated neutrophil extracellular trap (NET) formation and subsequent endothelial cell necrosis occur. Cyclophilin D (CypD) plays an important role in mediation of cell necrosis and inflammation via the opening of mitochondrial permeability transition pores. This study was undertaken to examine the role of CypD in AAV pathogenesis.

中文翻译：

髓过氧化物酶阳性抗中性粒细胞胞浆抗体相关性血管炎中亲环素 D 对 NETosis 和炎症的调节

抗中性粒细胞胞浆抗体（ANCA）相关性血管炎（AAV）的病理特征是局灶性纤维蛋白样坏死，其中ANCA介导的中性粒细胞胞外陷阱（NET）形成以及随后发生的内皮细胞坏死。亲环蛋白 D (CypD) 通过打开线粒体通透性转换孔在介导细胞坏死和炎症中发挥重要作用。本研究旨在探讨 CypD 在 AAV 发病机制中的作用。

更新日期：2022-07-29

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