Chemosensitivity-Gene Expression Correlations and Functional Enrichment Analysis Provide Insight into the Mechanism of Action of a Platinum-Acridine Anticancer Agent,ChemMedChem

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Chemosensitivity-Gene Expression Correlations and Functional Enrichment Analysis Provide Insight into the Mechanism of Action of a Platinum-Acridine Anticancer Agent
ChemMedChem ( IF 3.6 ) Pub Date : 2022-07-28 , DOI: 10.1002/cmdc.202200331
Haoqing Wu ₁ , Ulrich Bierbach ₁

Affiliation

A bioinformatics analysis of NCI-60 screening data suggest that DNA double-strand breaks (DSBs) and ribosome-biogenesis-related stress signaling play a major role in the cellular mechanism of action of a potent nucleolus-targeting platinum–acridine anticancer agent. These results support prior experimental data and are consistent with DNA being a major target of the hybrid agent based on the correlations observed between its potency and expression levels of genes implicated in DSB repair.

中文翻译：

化学敏感性-基因表达相关性和功能富集分析提供了对铂-吖啶类抗癌剂作用机制的深入了解

NCI-60 筛选数据的生物信息学分析表明，DNA 双链断裂 (DSB) 和核糖体生物发生相关的应激信号传导在有效的靶向核仁的铂-吖啶抗癌剂的细胞作用机制中起主要作用。这些结果支持先前的实验数据，并且与基于其效力与涉及 DSB 修复的基因的表达水平之间观察到的相关性作为混合剂的主要靶标的 DNA 是一致的。

更新日期：2022-07-28

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