Obstructive sleep apnea and serum total testosterone: a system review and meta-analysis,Sleep and Breathing

当前位置： X-MOL 学术 › Sleep Breath. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Obstructive sleep apnea and serum total testosterone: a system review and meta-analysis
Sleep and Breathing ( IF 2.1 ) Pub Date : 2022-07-29 , DOI: 10.1007/s11325-022-02655-6
Huihui Wang _{1,

2} , Jiyuan Lu ₁ , Lingdan Xu ₁ , Yanduo Yang ₁ , Yucheng Meng ₁ , Yi Li ₁ , Bin Liu ₁

Affiliation

Purpose

Testosterone deficiency (TD) negatively affects male sexuality, reproduction, general health, and quality of life. In recent years, decreased serum testosterone levels have been reported to be caused by obstructive sleep apnea (OSA). However, these results are controversial and lack the support of a large number of high-quality studies. Hence, we performed a meta-analysis to assess the association between OSA and serum testosterone levels.

Methods

To identify eligible studies, we conducted a systematic retrieval in the electronic databases (PubMed, Web of Science, the Cochrane Library, EMBASE) from their inception to September 2021. We chose studies with definitive diagnoses of OSA, including effects of OSA on testosterone level. Random effect model was used for analysis.

Results

This meta-analysis included 24 case–control studies with 1389 patients (1268 male patients) and 845 controls (745 male control). The serum testosterone levels in the male OSA group were significantly lower than that of control group [SMD = − 0.97, 95% CI (− 1.47, − 0.47)], while there was no difference in female patients with OSA and control [SMD = 0.06, 95% CI (− 0.22, 0.33)]. Subgroup analysis showed that race, age, body mass index (BMI), and detection method were the reason for high heterogeneity (I² = 94.9%).

Conclusions

The results indicated that OSA is significantly correlated with the decrease in serum testosterone levels in men. Male patients with OSA should be alerted to secondary diseases caused by low testosterone levels.

中文翻译：

阻塞性睡眠呼吸暂停和血清总睾酮：系统回顾和荟萃分析

目的

睾酮缺乏症 (TD) 会对男性性行为、生殖、一般健康和生活质量产生负面影响。近年来，据报道血清睾酮水平降低是由阻塞性睡眠呼吸暂停 (OSA) 引起的。然而，这些结果存在争议，缺乏大量高质量研究的支持。因此，我们进行了荟萃分析以评估 OSA 与血清睾酮水平之间的关联。

方法

为了确定符合条件的研究，我们对电子数据库（PubMed、Web of Science、Cochrane Library、EMBASE）从成立到 2021 年 9 月进行了系统检索。我们选择了明确诊断为 OSA 的研究，包括 OSA 对睾酮水平的影响. 使用随机效应模型进行分析。

结果

该荟萃分析包括 24 项病例对照研究，涉及 1389 名患者（1268 名男性患者）和 845 名对照者（745 名男性对照者）。男性 OSA 组的血清睾酮水平显着低于对照组 [SMD = − 0.97, 95% CI (− 1.47, − 0.47)]，而女性 OSA 患者与对照组无差异 [SMD = 0.06, 95% 置信区间 (− 0.22, 0.33)]。亚组分析表明，种族、年龄、体重指数（BMI）和检测方法是异质性高的原因（I ² = 94.9%）。