A nanopatterned poly(3,4-ethylenedioxythiophene) (PEDOT):Nafion composite layer integrated with interdigitated electrodes was developed to improve the device dynamic range and sensitivity for cellular impedance spectroscopy. The nanopattern fidelity to provide cellular alignment was accessed at different mixing volumes of PEDOT to Nafion. The ion transfer rate and electrical conductivity of Nafion were improved as the mixing ratio of PEDOT increased and it provided a uniform electrical path, thus giving conformable characteristics at all spectral frequencies from 1 kHz to 100 kHz for cellular impedance spectroscopy. Computational modeling was provided to extrapolate the electrical current flow and density in the composite with respect to the different frequency ranges. These results highlight that an electrically modified Nafion nanopattern interface, combined with interdigitated electrodes, can be used for various types of impedance-based cellular biosensors in a more biomimetic and sensitive manner.

中文翻译：

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通过纳米图案 PEDOT:Nafion 界面提高基于阻抗的细胞生物传感器的灵敏度

开发了一种纳米图案的聚 (3,4-乙烯二氧噻吩) (PEDOT):Nafion 复合层与叉指电极集成，以提高器件的动态范围和细胞阻抗谱的灵敏度。在 PEDOT 到 Nafion 的不同混合体积下访问了提供细胞排列的纳米图案保真度。Nafion 的离子转移率和电导率随着 PEDOT 混合比的增加而提高，并提供了均匀的电通路，从而在 1 kHz 至 100 kHz 的所有光谱频率下为细胞阻抗谱提供了一致的特性。提供了计算模型来推断复合材料中关于不同频率范围的电流流动和密度。