当前位置：
X-MOL 学术
›
Environ. Sci. Technol.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Niclosamide Exposure at Environmentally Relevant Concentrations Efficaciously Inhibited the Growth and Disturbed the Liver-Gut Axis of Adult Male Zebrafish
Environmental Science & Technology ( IF 10.8 ) Pub Date : 2022-07-28 , DOI: 10.1021/acs.est.2c02712 Biran Zhu 1, 2 , Lei Lei 1 , Yumiao Sun 1 , Xiongjie Shi 3 , Kaiyu Fu 1 , Jianghuan Hua 1, 2 , Christopher J Martyniuk 4 , Jian Han 1 , Lihua Yang 1 , Bingsheng Zhou 1
Environmental Science & Technology ( IF 10.8 ) Pub Date : 2022-07-28 , DOI: 10.1021/acs.est.2c02712 Biran Zhu 1, 2 , Lei Lei 1 , Yumiao Sun 1 , Xiongjie Shi 3 , Kaiyu Fu 1 , Jianghuan Hua 1, 2 , Christopher J Martyniuk 4 , Jian Han 1 , Lihua Yang 1 , Bingsheng Zhou 1
Affiliation
|
In the current study, adult male zebrafish fed a normal diet (ND) or high-fat diet (HFD) were exposed to niclosamide (NIC) at environmentally relevant concentrations to reveal the accumulation and distribution in different tissues and evaluate the effects on liver-gut axis. Chemical analysis indicated that the liver bore a greater burden of NIC compared with the brain and gonads in adult zebrafish, and the HFD-fed fish bore greater burden in their liver and brain than those ND-fed fish. The indications from body weight, growth rate, body mass index, micro-CT images, biochemical and pathological changes confirmed that NIC can efficaciously curb weight gain and improve overloads of in plasma insulin and glucose in HFD-fed zebrafish. However, the potential effects on liver-gut axis in ND-fed zebrafish were also elucidated: NIC disturbed mitochondrial energy production, inhibited the glycemic and triacylglycerol biosynthesis but promoted triacylglycerol and free fatty acid catabolism, therefore reduced lipid accumulation in hepatocytes; NIC also impaired the physical barrier, evoked inflammatory and oxidative stress and led to microbiota dysbiosis in the intestine. There findings highlighted the necessity for evaluating its potential impacts on the health of wild animals as well as human beings upon long-term exposure.
中文翻译：
环境相关浓度的氯硝柳胺暴露有效抑制成年雄性斑马鱼的生长并扰乱肝肠轴
在目前的研究中，喂食正常饮食（ND）或高脂饮食（HFD）的成年雄性斑马鱼暴露于环境相关浓度的氯硝柳胺（NIC），以揭示不同组织中的积累和分布，并评估对肝脏的影响-肠轴。化学分析表明，与成年斑马鱼的大脑和性腺相比，肝脏承受的 NIC 负担更大，喂食 HFD 的鱼比喂食 ND 的鱼的肝脏和大脑承受更大的负担。体重、生长速度、体重指数、显微 CT 图像、生化和病理变化的迹象证实，NIC 可以有效地抑制 HFD 喂养斑马鱼的体重增加并改善血浆胰岛素和葡萄糖的超负荷。然而，还阐明了 ND 喂养斑马鱼对肝肠轴的潜在影响：NIC 干扰线粒体能量产生，抑制血糖和甘油三酯的生物合成，但促进甘油三酯和游离脂肪酸的分解代谢，从而减少肝细胞中的脂质积累；NIC 还破坏了物理屏障，引起炎症和氧化应激，并导致肠道微生物群失调。研究结果强调了评估其长期接触对野生动物和人类健康的潜在影响的必要性。
更新日期：2022-07-28
中文翻译：
环境相关浓度的氯硝柳胺暴露有效抑制成年雄性斑马鱼的生长并扰乱肝肠轴
在目前的研究中，喂食正常饮食（ND）或高脂饮食（HFD）的成年雄性斑马鱼暴露于环境相关浓度的氯硝柳胺（NIC），以揭示不同组织中的积累和分布，并评估对肝脏的影响-肠轴。化学分析表明，与成年斑马鱼的大脑和性腺相比，肝脏承受的 NIC 负担更大，喂食 HFD 的鱼比喂食 ND 的鱼的肝脏和大脑承受更大的负担。体重、生长速度、体重指数、显微 CT 图像、生化和病理变化的迹象证实，NIC 可以有效地抑制 HFD 喂养斑马鱼的体重增加并改善血浆胰岛素和葡萄糖的超负荷。然而，还阐明了 ND 喂养斑马鱼对肝肠轴的潜在影响：NIC 干扰线粒体能量产生，抑制血糖和甘油三酯的生物合成，但促进甘油三酯和游离脂肪酸的分解代谢，从而减少肝细胞中的脂质积累；NIC 还破坏了物理屏障，引起炎症和氧化应激，并导致肠道微生物群失调。研究结果强调了评估其长期接触对野生动物和人类健康的潜在影响的必要性。
京公网安备 11010802027423号