Interfacial polymerization (IP) has been deemed as the principal strategy to fabricate thin film composite (TFC) nanofiltration (NF) membranes. However, the separation performances of TFC membrane are prone to be impaired with the issue of trade-off relationship between selectivity and permeability. Herein, a combined IP and in-situ sol-gel method was proposed to synthesis novel thin film nanocomposite (TFN) NF membrane. The nano-enhanced polyamide (PA) functional layer was created by the IP reaction, while the in-situ generated silicon dioxide (SiO₂) nanoparticles were formed through the hydrolysis and condensation process. The optimal separation performance was obtained by tailoring the formation process of SiO₂ nanoparticles via varying the NaOH concentration. The results revealed that the in-situ generated SiO₂ nanoparticles were uniformly distributed within the PA layer, which greatly enhanced the hydrophilicity due to the abundant Si-OH groups. The membrane decorated by 1 ml TEOS under 0.3 wt% NaOH condition possessed a pure water permeability up to 70.69 L m⁻² h⁻¹ bar⁻¹ and high rejection rates against dyes (99.99 % for Congo red, 99.55 % for Coomassie blue G-250, 99.39 % for Reactive blue 19), while maintaining low salt rejections (4.92 % for NaCl, 7.14 % for Na₂SO₄). Meanwhile, the membrane presented an excellent long-term operational stability.

界面聚合 (IP) 已被认为是制造薄膜复合 (TFC) 纳滤 (NF) 膜的主要策略。然而，由于选择性和渗透性之间的权衡关系问题，TFC膜的分离性能容易受到影响。在此，提出了一种结合 IP 和原位溶胶-凝胶的方法来合成新型薄膜纳米复合材料 (TFN) NF 膜。纳米增强聚酰胺（PA）功能层通过IP反应形成，而原位生成的二氧化硅（SiO ₂）纳米颗粒通过水解和缩合过程形成。_{通过调整 SiO 2}的形成工艺获得最佳分离性能纳米颗粒通过改变 NaOH 浓度。结果表明，原位生成的SiO ₂纳米粒子均匀分布在PA层内，由于丰富的Si-OH基团，大大增强了亲水性。^{在 0.3 wt% NaOH 条件下用 1 ml TEOS 装饰的膜具有高达 70.69 L m -2}  h ^-1  bar ^-1的纯水渗透率和对染料的高截留率（刚果红为 99.99 %，考马斯蓝 G 为 99.55 % -250，活性蓝 19 为 99.39 %），同时保持低脱盐率（NaCl 为 4.92 %，Na ₂ SO _{4为 7.14 %}）。同时，该膜呈现出优异的长期运行稳定性。