Although it is understood that myriad proteins function in cells within biomolecular condensates, it is unclear how protein condensation is altered in human disease. In this issue of Developmental Cell, Banani et al. show that mutations in disease-associated proteins may map to phase-separation-prone regions and thereby alter condensate formation.

中文翻译：

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绘制人类疾病凝集失调症

尽管人们知道无数蛋白质在生物分子凝聚物中的细胞中起作用，但尚不清楚蛋白质凝聚物在人类疾病中是如何改变的。在本期《发育细胞》中，Banani 等人。表明疾病相关蛋白的突变可能映射到易于相分离的区域，从而改变冷凝物的形成。