In a recent issue of Cell, Yang et al. utilize evolvable cellular barcodes to investigate the evolutionary trajectories of murine lung adenocarcinoma. Reconstructing the life histories of these tumors based on cellular barcodes reveals stringent selection and phenotypic differences across subclonal lineages.

中文翻译：

---

“致命”遭遇：谱系追踪与系统发育相遇，以解开癌症进展的奥秘

在最近一期的Cell上，Yang 等人。利用可进化的细胞条形码来研究鼠肺腺癌的进化轨迹。基于细胞条形码重建这些肿瘤的生活史揭示了亚克隆谱系之间的严格选择和表型差异。