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Defining clinically important overall survival thresholds: lessons from quality of life
Nature Reviews Clinical Oncology ( IF 81.1 ) Pub Date : 2022-07-27 , DOI: 10.1038/s41571-022-00667-5
Bishal Gyawali 1, 2, 3, 4 , Christopher M Booth 1, 2, 3, 4
Affiliation  

In randomized controlled trials in oncology, changes in quality of life are usually reported together with a description of the differences considered a priori to be clinically important, but overall survival outcomes are rarely provided together with information of what constitutes a clinically meaningful threshold. In this Comment, we propose the benefits that could be derived from reporting overall survival in a similar way to quality of life.

中文翻译:

定义临床上重要的总体生存阈值:生活质量的经验教训

在肿瘤学的随机对照试验中,生活质量的变化通常与被认为具有临床重要性的差异描述一起报告,但很少提供总体生存结果以及构成临床意义阈值的信息。在本评论中,我们提出了以与生活质量类似的方式报告总生存期可能带来的好处。
更新日期:2022-07-28
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