Acute exacerbations of asthma are an important and unmet asthma need [1], responsible for considerable morbidity and economic cost, across all age groups [2]. The most common triggers are acute viral infections and seasonal allergen exposure [1, 3]. This close epidemiological relationship is demonstrated by the fact that the prevalence of endemic rhinovirus is the commonest predictor of acute asthma in children, while in adults, the winter peak of asthma exacerbations remains strongly associated with influenza and other respiratory viruses [4].

中文翻译：

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我们需要了解为什么病毒感染会导致急性哮喘

哮喘急性发作是一项重要且未得到满足的哮喘需求 [1]，在所有年龄组中造成了相当大的发病率和经济成本 [2]。最常见的诱因是急性病毒感染和季节性过敏原暴露 [1, 3]。这种密切的流行病学关系通过以下事实证明：地方性鼻病毒的流行是儿童急性哮喘最常见的预测因子，而在成人中，哮喘恶化的冬季高峰仍然与流感和其他呼吸道病毒密切相关 [4]。