Several cytokines and growth factors start and progress the destruction process of joint hyaline cartilage and fibrosis formation. Captopril is classified as an Angiotensin-converting enzyme inhibitor in which several studies revealed that captopril significantly decreases fibrosis formation in some organs like the liver, heart, and kidney. This study aimed to evaluate the use of captopril in reducing the possibility of arthrofibrosis and osteoarthritis in an animal model. In this in-vivo animal model study, the anterior cruciate ligament of 24 rabbits was transected to induce osteoarthritis and arthrofibrosis. The control group contained 11 rabbits and the second group consisted of 13 rabbits. The second group was treated with 10 mg/ kilogram/day captopril through a nasogastric tube. The control group was treated with normal saline in the same way. Cartilage damage and osteoarthritis were evaluated by Osteoarthritis Research Society International (OARSI) scoring system. After 30 days, animals were sacrificed, and arthrofibrosis and cartilage damage were evaluated microscopically and macroscopically. According to macroscopic and microscopic evaluation, captopril dramatically reduced arthrofibrosis formation based on visual scoring and the Masson trichrome staining system. Cartilage damage was lower in the intervention group compared to the control group. Captopril is an angiotensin-converting enzyme inhibitor that demonstrated to significantly decreases the possibility of arthrofibrosis. Although the beneficial preventive effect of captopril on osteoarthritis was not proved statistically, better results may be obtained if the route of administration or drug dosage is changed.

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卡托普利改善膝关节纤维化和软骨状态的有希望的结果：动物模型研究

几种细胞因子和生长因子启动和推进关节透明软骨和纤维化形成的破坏过程。卡托普利被归类为血管紧张素转换酶抑制剂，其中多项研究表明，卡托普利可显着减少某些器官（如肝脏、心脏和肾脏）的纤维化形成。本研究旨在评估在动物模型中使用卡托普利降低关节纤维化和骨关节炎的可能性。在这项体内动物模型研究中，24 只兔子的前交叉韧带被横断以诱发骨关节炎和关节纤维化。对照组包含11只兔子，第二组包含13只兔子。第二组通过鼻胃管用 10 mg/kg/天的卡托普利治疗。对照组用生理盐水同法处理。通过国际骨关节炎研究协会 (OARSI) 评分系统评估软骨损伤和骨关节炎。30天后，处死动物，用显微镜和肉眼评估关节纤维化和软骨损伤。根据宏观和微观评估，基于视觉评分和马森三色染色系统，卡托普利显着减少了关节纤维化的形成。与对照组相比，干预组的软骨损伤较低。卡托普利是一种血管紧张素转换酶抑制剂，可显着降低关节纤维化的可能性。尽管卡托普利对骨关节炎的有益预防作用尚未得到统计证明，