Background and Hypothesis Maternal schizophrenia heightens the risk for certain perinatal complications, yet it is not known to what degree future childhood chronic health conditions (Childhood-CC) might arise. Study Design This population-based cohort study using health administrative data from Ontario, Canada (1995–2018) compared 5066 children of mothers with schizophrenia to 25 324 children of mothers without schizophrenia, propensity-matched on birth-year, maternal age, parity, immigrant status, income, region of residence, and maternal medical and psychiatric conditions other than schizophrenia. Cox proportional hazard models generated hazard ratios (HR) and 95% confidence intervals (CI) for incident Childhood-CCs, and all-cause mortality, up to age 19 years. Study Results Six hundred and fifty-six children exposed to maternal schizophrenia developed a Childhood-CC (20.5/1000 person-years) vs. 2872 unexposed children (17.1/1000 person-years)—an HR of 1.18, 95% CI 1.08–1.28. Corresponding rates were 3.3 vs. 1.9/1000 person-years (1.77, 1.44–2.18) for mental health Childhood-CC, and 18.0 vs. 15.7/1000 person-years (1.13, 1.04–1.24) for non-mental health Childhood-CC. All-cause mortality rates were 1.2 vs. 0.8/1000 person-years (1.34, 0.96–1.89). Risk for children exposed to maternal schizophrenia was similar whether or not children were discharged to social service care. From age 1 year, risk was greater for children whose mothers were diagnosed with schizophrenia prior to pregnancy than for children whose mothers were diagnosed with schizophrenia postnatally. Conclusions A child exposed to maternal schizophrenia is at elevated risk of chronic health conditions including mental and physical subtypes. Future research should examine what explains the increased risk particularly for physical health conditions, and what preventive and treatment efforts are needed for these children.

中文翻译：

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母亲精神分裂症和儿童慢性病的风险

背景和假设 母亲精神分裂症会增加某些围产期并发症的风险，但尚不清楚未来儿童慢性健康状况 (Childhood-CC) 可能出现的程度。研究设计 这项基于人群的队列研究使用加拿大安大略省（1995-2018）的卫生行政数据，将 5066 名患有精神分裂症母亲的孩子与 25 324 名没有精神分裂症母亲的孩子进行了比较，在出生年份、母亲年龄、胎次、移民身份、收入、居住地区以及精神分裂症以外的产妇医疗和精神疾病。Cox 比例风险模型生成了 19 岁以下儿童 CC 事件和全因死亡率的风险比 (HR) 和 95% 置信区间 (CI)。研究结果 656 名接触过母亲精神分裂症的儿童发展为儿童期 CC（20.5/1000 人年），而 2872 名未接触过精神分裂症的儿童（17.1/1000 人年）——HR 为 1.18，95% CI 1.08—— 1.28。心理健康童年-CC 的相应比率为 3.3 与 1.9/1000 人年（1.77、1.44-2.18），非心理健康童年-CC 的相应比率为 18.0 与 15.7/1000 人年（1.13、1.04-1.24）。抄送。全因死亡率分别为 1.2 比 0.8/1000 人年 (1.34、0.96–1.89)。无论儿童是否出院接受社会服务护理，儿童患孕产妇精神分裂症的风险相似。从 1 岁起，母亲在怀孕前被诊断出患有精神分裂症的孩子的风险高于母亲在产后被诊断出患有精神分裂症的孩子。结论 患有精神分裂症的母亲的孩子患慢性健康问题（包括精神和身体亚型）的风险较高。未来的研究应该探讨如何解释尤其是身体健康状况风险增加的原因，以及这些儿童需要采取哪些预防和治疗措施。