Hollow Aluminum Hydroxide Modified Silica Nanoadjuvants with Amplified Immunotherapy Effects through Immunogenic Cell Death Induction and Antigen Release,Small

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Hollow Aluminum Hydroxide Modified Silica Nanoadjuvants with Amplified Immunotherapy Effects through Immunogenic Cell Death Induction and Antigen Release
Small ( IF 13.0 ) Pub Date : 2022-07-27 , DOI: 10.1002/smll.202202462
Jia Tan _{1,

2} , Binbin Ding ₁ , Pan Zheng _{1,

3} , Hao Chen _{1,

2} , Ping'an Ma _{1,

2} , Jun Lin _{1,

2}

Affiliation

In spite of the widespread application of vaccine adjuvants in various preventive vaccines at present, the existing adjuvants are still hindered by weak cellular immunity responses in therapeutic cancer vaccines. Herein, a hollow silica nanoadjuvant containing aluminum hydroxide spikes on the surface (SiAl) is synthesized for the co-loading of chemotherapeutic drug doxorubicin (Dox) and tumor fragment (TF) as tumor antigens (SiAl@Dox@TF). The obtained nanovaccines show significantly elevated anti-tumor immunity responses thanks to silica and aluminum-based composite nanoadjuvant-mediated tumor antigen release and Dox-induced immunogenic cell death (ICD). In addition, the highest frequencies of dendritic cells (DCs), CD4⁺ T cells, CD8⁺ T cells, and memory T cells as well as the best mice breast cancer (4T1) tumor growth inhibitory are also observed in SiAl@Dox@TF group, indicating favorable potential of SiAl nanoadjuvants for further applications. This work is believed to provide inspiration for the design of new-style nanoadjuvants and adjuvant-based cancer vaccines.

中文翻译：

空心氢氧化铝改性二氧化硅纳米佐剂通过免疫原性细胞死亡诱导和抗原释放增强免疫治疗效果

尽管目前疫苗佐剂在各种预防性疫苗中得到广泛应用，但现有佐剂在治疗性癌症疫苗中仍受到细胞免疫反应较弱的阻碍。在此，合成了一种表面含有氢氧化铝尖峰（SiAl）的中空二氧化硅纳米佐剂，用于共同负载化疗药物阿霉素（Dox）和肿瘤片段（TF）作为肿瘤抗原（SiAl@Dox@TF）。由于二氧化硅和铝基复合纳米佐剂介导的肿瘤抗原释放和 Dox 诱导的免疫原性细胞死亡 (ICD)，所获得的纳米疫苗显示出显着提高的抗肿瘤免疫反应。此外，树突状细胞 (DC)、CD4 ⁺ T 细胞、CD8 ⁺在 SiAl@Dox@TF 组中也观察到 T 细胞和记忆 T 细胞以及最好的小鼠乳腺癌 (4T1) 肿瘤生长抑制作用，表明 SiAl 纳米佐剂具有良好的进一步应用潜力。相信这项工作将为设计新型纳米佐剂和基于佐剂的癌症疫苗提供灵感。

更新日期：2022-07-27

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