Three in one: three valid pharmacophores (indole, pyranone and trifluoromethyl) were successfully combined into one molecule by rhodium-catalyzed regioselective annulation of indole carboxylic acids with unsymmetric internal trifluoromethylated alkynes.

中文翻译：

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三氟甲基化吲哚并吡喃酮通过吲哚羧酸与不对称内部三氟甲基化炔烃的区域选择性环化

三合一：通过铑催化的吲哚羧酸与不对称的内部三氟甲基化炔烃的区域选择性环化，三种有效的药效团（吲哚、吡喃酮和三氟甲基）成功地结合成一个分子。