The D-proline-catalyzed Mannich reaction of an imine and a protected dioxanone is described as the key step for the stereoselective synthesis of a series of L-lyxo and L-xylo- pentofuranose-mimetic iminosugars and derivatives. The L-lyxo derivative 12, has emerged as head of series, seeking for the development of novel glycomimetics with potential activity towards pathogenic trypanosomatids.

中文翻译：

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L-呋喃戊糖模拟亚氨基糖的有机催化合成及抗锥虫活性评价

D-脯氨酸催化的亚胺和受保护的二恶烷酮的曼尼希反应被描述为立体选择性合成一系列 L - lyxo和 L-木糖-呋喃戊糖模拟亚氨基糖及其衍生物的关键步骤。L -lyxo衍生物12已成为系列的负责人，寻求开发对致病性锥虫具有潜在活性的新型糖模拟物。