Heated tobacco products and electronic cigarettes are considered as alternatives to traditional tobacco cigarettes. However, it is crucial to monitor and compare the nicotine concentration in inhaled aerosols from these tobacco products, owing to the addictive nature and adverse effects of nicotine on human health. This study aimed to provide an electromembrane extraction (EME) combined liquid chromatography method to extract and determine nicotine in different inhaled aerosols. EME showed high extraction efficiency, selectivity, and sample clean-up capability. Under the optimal parameters, the linear range for nicotine was 0.1–200 mg L⁻¹ (r² > 0.9998), and the limit of detection was 0.02 mg L⁻¹. Good precision was obtained with the intra- and inter-day relative standard deviations of 2.2 % and 2.8 %, respectively. Repeatability was satisfactory (<7.7 %), and recoveries ranged from 81.0 % to 112.8 %. Finally, this method has been successfully used for the determination and comparison of nicotine in aerosols from these three tobacco products.

加热烟草产品和电子烟被认为是传统烟草卷烟的替代品。然而，由于尼古丁的成瘾性和对人类健康的不利影响，监测和比较这些烟草制品吸入气溶胶中的尼古丁浓度至关重要。本研究旨在提供一种电膜萃取（EME）联合液相色谱方法来提取和测定不同吸入气溶胶中的尼古丁。 EME 显示出高萃取效率、选择性和样品净化能力。在最佳参数下，尼古丁的线性范围为0.1~200 mg L ^-1 (r ² > 0.9998)，检测限为0.02 mg L ^-1 。获得了良好的精度，日内和日间相对标准偏差分别为 2.2% 和 2.8%。重复性令人满意 (<7.7%)，回收率范围为 81.0% 至 112.8%。最后，该方法已成功用于这三种烟草制品气溶胶中尼古丁的测定和比较。