Mechanical forces exerted on neural crest cells control their collective migration and differentiation. This perspective discusses our current understanding of neural crest mechanotransduction during cell migration and differentiation. Additionally, we describe proteins that have mechanosensitive functions in other systems, such as mechanosensitive G-protein-coupled receptors, mechanosensitive ion channels, cell-cell adhesion, and cell-matrix-interacting proteins, and highlight that these same proteins have in the past been studied in neural crest development from a purely signaling point of view. We propose that future studies elucidate the mechanosensitive functions these receptors may play in neural crest development and integrate this with their known molecular role.

施加在神经嵴细胞上的机械力控制着它们的集体迁移和分化。这个观点讨论了我们目前对细胞迁移和分化过程中神经嵴机械转导的理解。此外，我们描述了在其他系统中具有机械敏感性功能的蛋白质，例如机械敏感性 G 蛋白偶联受体、机械敏感性离子通道、细胞-细胞粘附和细胞-基质相互作用蛋白，并强调这些相同的蛋白质在过去具有从纯粹的信号角度研究了神经嵴发育。我们建议未来的研究阐明这些受体可能在神经嵴发育中发挥的机械敏感性功能，并将其与其已知的分子作用相结合。