Evaluation of site-diversified, fully functionalized diazirine probes for chemical proteomic applications,Chemical Communications

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Evaluation of site-diversified, fully functionalized diazirine probes for chemical proteomic applications
Chemical Communications ( IF 4.3 ) Pub Date : 2022-07-27 , DOI: 10.1039/d2cc03868d
Yan Tan _{1,

2} , Songsen Fu _{1,

2} , Tao Yang _{1,

2} , Yuxin Xie ₃ , Guyi Shen ₃ , Jie Yan ₃ , Yufen Zhao _{1,

2} , Feng Ni _{1,

2,

3}

Affiliation

A series of site-diversified, fully functionalized diazirine probes are constructed based on a scaffold shared by several marketed EGFR-targeted drugs. The integrated analysis of protein targets of the site-diversified probe toolkit not only unveils more complete target space and helps suggest false positive targets, but also reveals dynamic events of multi-domain target-ligand interaction.

中文翻译：

评估用于化学蛋白质组学应用的位点多样化、完全功能化的二氮丙啶探针

基于几种已上市的 EGFR 靶向药物共享的支架，构建了一系列位点多样化、功能齐全的二氮丙啶探针。位点多样化探针工具包对蛋白质靶点的综合分析不仅揭示了更完整的靶点空间并有助于提示假阳性靶点，而且揭示了多域靶点-配体相互作用的动态事件。

更新日期：2022-07-27

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