Reconsidering vitamin D optimal values based on parathyroid hormone levels in a North Algerian cohort: stratification by gender and season,Archives of Osteoporosis

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Reconsidering vitamin D optimal values based on parathyroid hormone levels in a North Algerian cohort: stratification by gender and season
Archives of Osteoporosis ( IF 3.1 ) Pub Date : 2022-07-27 , DOI: 10.1007/s11657-022-01137-2
Salam Bennouar ₁ , Abdelghani Bachir Cherif ₂ , Mohamed Makrelouf ₃ , Belaid Ait Abdelkader ₄ , Abdelhalim Taleb ₂ , Samia Abdi ₁

Affiliation

Summary

“Health-based threshold value” is used to define the optimal cutoff of vitamin D. This approach is based on the hypothesis of a secondary hyperparathyroidism associated with hypovitaminosis D. We define the optimal values in a North Algerian population. The optimal value is 25.0 ng/ml in men and 30.0 ng/ml in women.

Purpose/Introduction

There is no consensus defining the vitamin D optimal values. The aim of this study is to establish vitamin D optimal values in the Northern Algerian population, based on its skeletal effects as represented by the inverse relationship between 25-hydroxy vitamin D (25(OH) D) and parathyroid hormone (PTH).

Methods

451 healthy volunteers of both genders, aged 19 to 79 years, were enrolled in a cross-sectional study conducted at the medical analysis laboratory of the University Hospital of Blida, Algeria. 25(OH) D was assessed by a sequential competitive immuno-fluoroassay technique. Determination of vitamin D optimal values was performed based on the kinetic relationship between 25(OH) D and PTH, as explored by inverse nonlinear regression on a spline plots curve. The optimal value represents the 25(OH) D level at which PTH ceases to increase and reaches a virtual plateau.

Results

In men and women, respectively, the 25 (OH) D thresholds are estimated at 25.0 ng/ml and 30 ng/ml, above this value, PTH stabilizes in a virtual plateau, estimated at 22.3 pg/ml and 26.8 pg/ml. In warm and cold seasons, respectively, the 25 (OH) D cut-offs are estimated at 30.0 ng/ml and 25.0 ng/ml, from these values, the PTH stabilizes in a virtual plateau, estimated at 21.5 pg/ml and 27.7 pg/ml.

Conclusion

In this study, the optimal values of 25(OH) D were defined for the first time in a North Algerian adult population. The optimal value is 25.0 ng/ml in men and 30.0 ng/ml in women.

中文翻译：

重新考虑基于北阿尔及利亚队列中甲状旁腺激素水平的维生素 D 最佳值：按性别和季节分层

概括

“基于健康的阈值”用于定义维生素 D 的最佳截止值。这种方法基于与维生素 D 缺乏症相关的继发性甲状旁腺功能亢进症的假设。我们定义了阿尔及利亚北部人口的最佳值。男性的最佳值为 25.0 ng/ml，女性为 30.0 ng/ml。

目的/介绍

没有定义维生素 D 最佳值的共识。本研究的目的是根据 25-羟基维生素 D (25(OH) D) 和甲状旁腺激素 (PTH) 之间的反比关系所代表的骨骼效应，确定阿尔及利亚北部人群的维生素 D 最佳值。

方法

451 名年龄在 19 至 79 岁之间的健康志愿者参加了一项横断面研究，该研究在阿尔及利亚卜利达大学医院的医学分析实验室进行。25(OH) D 通过序贯竞争性免疫荧光测定技术进行评估。维生素 D 最佳值的确定是根据 25(OH) D 和 PTH 之间的动力学关系进行的，如样条曲线上的逆非线性回归所探索的那样。最佳值表示 25(OH) D 水平，此时 PTH 停止增加并达到虚拟平台。

结果

在男性和女性中，25 (OH) D 阈值分别估计为 25.0 ng/ml 和 30 ng/ml，高于此值，PTH 稳定在一个虚拟平台，估计为 22.3 pg/ml 和 26.8 pg/ml。在温暖和寒冷的季节，25 (OH) D 的临界值分别估计为 30.0 ng/ml 和 25.0 ng/ml，根据这些值，PTH 稳定在一个虚拟平台，估计为 21.5 pg/ml 和 27.7皮克/毫升。