Hydroxychloroquine sulfate is effective in the treatment of malaria and autoimmune diseases and as an antiviral drug. However, unreported impurities are often detected in this drug, which pose a health risk. In this study, the structures of hydroxychloroquine and six unknown impurities were analyzed using ultra-high-performance liquid chromatography-quadrupole/time-of-flight-tandem mass spectrometry (UHPLC­Q/TOF/MS/MS), and the structures were characterized using liquid chromatography-solid-phase extraction-nuclear magnetic resonance (LC-SPE-NMR) spectroscopy.

中文翻译：

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使用超高效液相色谱-四极杆/飞行时间质谱和液相色谱-固相萃取-核磁共振对重新利用的 COVID-19 药物硫酸羟氯喹中的杂质进行研究

硫酸羟氯喹可有效治疗疟疾和自身免疫性疾病，并可作为抗病毒药物。然而，在这种药物中经常会检测到未报告的杂质，这会带来健康风险。本研究采用超高效液相色谱-四极杆/飞行时间-串联质谱 (UHPLCQ/TOF/MS/MS) 对羟氯喹和 6 种未知杂质的结构进行了分析，并采用液相色谱-固相萃取-核磁共振（LC-SPE-NMR）光谱。