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Construction of Folate-Conjugated and pH-Responsive Cell Membrane Mimetic Mixed Micelles for Desirable DOX Release and Enhanced Tumor-Cellular Target
Langmuir ( IF 3.7 ) Pub Date : 2022-07-26 , DOI: 10.1021/acs.langmuir.2c00905 Haimei Cao 1 , Meijun Yi 1 , Henan Wei 1 , Shiping Zhang 1
Langmuir ( IF 3.7 ) Pub Date : 2022-07-26 , DOI: 10.1021/acs.langmuir.2c00905 Haimei Cao 1 , Meijun Yi 1 , Henan Wei 1 , Shiping Zhang 1
Affiliation
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Smart multifunctional polymeric micelles are in urgent demand for future cancer diagnosis and therapy. In this paper, doxorubicin (DOX)-loaded folic acid (FA)-targeting and pH-responsive cell membrane mimetic mixed micelles of P(DMAEMA-co-MaPCL) (PCD) and FA-P(MPC-co-MaPCL) (PMCF) (mass ratio 5/5) were prepared by a dialysis method. The micelle size, morphology, X-ray powder diffraction (XRD), pH responsiveness, in vitro DOX release, cytotoxicity, and cellular uptake were studied in detail. The results indicated that DOX could be efficiently loaded into mixed micelles (PDMCF micelles), and the DOX-loaded mixed micelles (DOX@PDMCF micelles) exhibited a size of 150 nm and pH-responsive DOX release in an extended period. Furthermore, the DOX@PDMCF micelles could efficiently suppress the proliferation of tumor cells, HeLa and MCF-7 cells. Our data suggest that the DOX@PDMCF micelles have the potential to be applied in tumor therapy, especially for treating various folate receptor overexpressed tumors.
中文翻译：
构建叶酸偶联和 pH 响应细胞膜模拟混合胶束以实现理想的 DOX 释放和增强的肿瘤细胞靶点
智能多功能聚合物胶束是未来癌症诊断和治疗的迫切需求。在本文中，阿霉素（DOX）负载叶酸（FA）靶向和pH响应细胞膜模拟P（DMAEMA- co - MaPCL）（PCD）和FA-P（ MPC- co -MaPCL）的混合胶束（ PMCF) (质量比5/5)通过透析法制备。胶束尺寸、形貌、X射线粉末衍射（XRD）、pH响应性、体外详细研究了 DOX 释放、细胞毒性和细胞摄取。结果表明，DOX 可以有效地负载到混合胶束（PDMCF 胶束）中，负载 DOX 的混合胶束（DOX@PDMCF 胶束）表现出 150 nm 的尺寸和 pH 响应的 DOX 释放时间。此外，DOX@PDMCF胶束可以有效抑制肿瘤细胞、HeLa和MCF-7细胞的增殖。我们的数据表明 DOX@PDMCF 胶束具有应用于肿瘤治疗的潜力，特别是用于治疗各种叶酸受体过表达的肿瘤。
更新日期：2022-07-26
中文翻译：
构建叶酸偶联和 pH 响应细胞膜模拟混合胶束以实现理想的 DOX 释放和增强的肿瘤细胞靶点
智能多功能聚合物胶束是未来癌症诊断和治疗的迫切需求。在本文中，阿霉素（DOX）负载叶酸（FA）靶向和pH响应细胞膜模拟P（DMAEMA- co - MaPCL）（PCD）和FA-P（ MPC- co -MaPCL）的混合胶束（ PMCF) (质量比5/5)通过透析法制备。胶束尺寸、形貌、X射线粉末衍射（XRD）、pH响应性、体外详细研究了 DOX 释放、细胞毒性和细胞摄取。结果表明，DOX 可以有效地负载到混合胶束（PDMCF 胶束）中，负载 DOX 的混合胶束（DOX@PDMCF 胶束）表现出 150 nm 的尺寸和 pH 响应的 DOX 释放时间。此外，DOX@PDMCF胶束可以有效抑制肿瘤细胞、HeLa和MCF-7细胞的增殖。我们的数据表明 DOX@PDMCF 胶束具有应用于肿瘤治疗的潜力，特别是用于治疗各种叶酸受体过表达的肿瘤。
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