当前位置: X-MOL 学术Mol. Psychiatry › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Alcohol consumption and telomere length: Mendelian randomization clarifies alcohol’s effects
Molecular Psychiatry ( IF 9.6 ) Pub Date : 2022-07-26 , DOI: 10.1038/s41380-022-01690-9
A Topiwala 1 , B Taschler 2 , K P Ebmeier 3 , S Smith 2 , H Zhou 4, 5 , D F Levey 4, 5 , V Codd 6, 7 , N J Samani 6, 7 , J Gelernter 4, 5 , T E Nichols 1, 2 , S Burgess 8, 9
Affiliation  

Alcohol’s impact on telomere length, a proposed marker of biological aging, is unclear. We performed the largest observational study to date (in n = 245,354 UK Biobank participants) and compared findings with Mendelian randomization (MR) estimates. Two-sample MR used data from 472,174 participants in a recent genome-wide association study (GWAS) of telomere length. Genetic variants were selected on the basis of associations with alcohol consumption (n = 941,280) and alcohol use disorder (AUD) (n = 57,564 cases). Non-linear MR employed UK Biobank individual data. MR analyses suggested a causal relationship between alcohol traits, more strongly for AUD, and telomere length. Higher genetically-predicted AUD (inverse variance-weighted (IVW) β = −0.06, 95% confidence interval (CI): −0.10 to −0.02, p = 0.001) was associated with shorter telomere length. There was a weaker association with genetically-predicted alcoholic drinks weekly (IVW β = −0.07, CI: −0.14 to −0.01, p = 0.03). Results were consistent across methods and independent from smoking. Non-linear analyses indicated a potential threshold relationship between alcohol and telomere length. Our findings indicate that alcohol consumption may shorten telomere length. There are implications for age-related diseases.



中文翻译:


饮酒量和端粒长度:孟德尔随机化阐明了酒精的影响



酒精对端粒长度(生物衰老的一个拟议标志)的影响尚不清楚。我们进行了迄今为止最大规模的观察性研究( n = 245,354 名英国生物银行参与者),并将研究结果与孟德尔随机化 (MR) 估计值进行了比较。两个样本 MR 使用了最近一项端粒长度全基因组关联研究 (GWAS) 中 472,174 名参与者的数据。根据与饮酒( n = 941,280)和酒精使用障碍(AUD)( n = 57,564 例)的关联来选择遗传变异。非线性MR采用英国生物银行个体数据。 MR 分析表明,酒精特征(对于 AUD 而言更为强烈)与端粒长度之间存在因果关系。较高的遗传预测 AUD(逆方差加权 (IVW) β = -0.06,95% 置信区间 (CI):-0.10 至 -0.02, p = 0.001)与较短的端粒长度相关。与基因预测的每周饮酒量的相关性较弱(IVW β = -0.07,CI:-0.14 至 -0.01, p = 0.03)。不同方法的结果是一致的,并且与吸烟无关。非线性分析表明酒精和端粒长度之间存在潜在的阈值关系。我们的研究结果表明,饮酒可能会缩短端粒长度。这对与年龄相关的疾病有影响。

更新日期:2022-07-26
down
wechat
bug