Abstract

Objective

The aim of this study was to analyse the relationship between physical activity and the incidence of dementia in a cohort of people aged 50 years or older without dementia from different countries in Europe between the years 2013 and 2015.

Methods

Prospective longitudinal design study (2013-2015) with a sample of 46,141 people without dementia in 2013 who participated in the SHARE project in waves 5 and 6, where 15 European countries participated. We defined dementia as a self-report of Alzheimer’s disease, organic brain syndrome, senility, or any other serious memory impairment during follow-up. The frequency of moderate, vigorous and moderate-to-vigorous physical activity in 2013 was obtained from a validated questionnaire. Incidences of dementia by year (between 2013 and 2015) were calculated for each category of physical activity. Poisson regression models with robust variance were fitted for the association between physical activity and dementia.

Results

The incidence of dementia was 7.4 [95%CI = 6.8-7.9] cases per 1000 persons per year. Very frequent moderate physical activity is a protective factor for dementia independently of the frequency of vigorous physical activity and inversely. The risk of dementia was 2.36 [95%CI = 1.77-3.14] higher in people who hardly ever, or never did moderate-to-vigorous physical activity comparing to people engaged in it more than once a week independently of the baseline cognitive level.

Conclusion

Physical activity is associated with the incidence of dementia in people aged 50 and over in both men and women in Europe.

中文翻译：

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欧洲 50 岁及以上人群体力活动与痴呆症发病率的关系

摘要

客观的

本研究的目的是分析 2013 年至 2015 年间来自欧洲不同国家的 50 岁或以上未患痴呆症人群的体力活动与痴呆症发病率之间的关系。

方法

前瞻性纵向设计研究（2013-2015），样本为 2013 年参与第 5 波和第 6 波 SHARE 项目的 46,141 名无痴呆症患者，其中有 15 个欧洲国家参与。我们将痴呆症定义为在随访期间自我报告的阿尔茨海默病、器质性脑综合症、衰老或任何其他严重的记忆障碍。2013 年中度、剧烈和中度至剧烈体力活动的频率是从经过验证的问卷中获得的。按年份（2013 年至 2015 年）计算每种体育活动类别的痴呆症发病率。具有稳健方差的泊松回归模型适合体力活动与痴呆之间的关联。

结果

痴呆症发病率为每年每 1000 人 7.4 例 [95%CI = 6.8-7.9] 例。非常频繁的中等体力活动是痴呆症的保护因素，与剧烈体力活动的频率无关，反之亦然。与每周进行一次以上体力活动的人相比，几乎不进行或从未进行过中度至剧烈体力活动的人患痴呆症的风险要高 2.36 [95%CI = 1.77-3.14]，与基线认知水平无关。

结论

在欧洲，体力活动与 50 岁及以上男性和女性的痴呆症发病率相关。