Background Some amino acids have been associated with aging-related disorders and risk of physical impairment. The aim of this study was to assess the association between plasma concentrations of nine amino acids, including branched-chain and aromatic amino acids, and multimorbidity. Methods This research uses longitudinal data from the Seniors-ENRICA 2 study, a population-based cohort from Spain which comprises non-institutionalized adults older than 65. Blood samples were extracted at baseline and after a follow-up period of two years for a total of 1488 subjects. Participants’ information was linked with electronic health records. Chronic diseases were grouped into a list of 60 mutually exclusive conditions. A quantitative measure of multimorbidity, weighting morbidities by their regression coefficients on physical functioning, was employed and ranged from 0 to 100. Generalized estimating equation models were used to explore the relationship between plasma amino acids and multimorbidity, adjusting for sociodemographics, socioeconomic status and lifestyle behaviors. Results The mean age of participants at baseline was 73.6 (SD = 4.2) years, 49.6% were women. Higher concentrations of glutamine [coef. per mmol/l (95% confidence interval = 10.1 (3.7, 16.6)], isoleucine [50.3 (21.7, 78.9)] and valine [15.5 (3.1, 28.0)] were significantly associated with higher multimorbidity scores, after adjusting for potential confounders. Body mass index could have influenced the relationship between isoleucine and multimorbidity (p = 0.016). Conclusions Amino acids could play a role in regulating aging-related diseases. Glutamine and branched-chain amino acids as isoleucine and valine are prospectively associated and could serve as risk markers for multimorbidity in older adults.

中文翻译：

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老年人血浆氨基酸与多种疾病之间的前瞻性关联

背景 某些氨基酸与衰老相关疾病和身体损伤风险有关。本研究的目的是评估九种氨基酸（包括支链氨基酸和芳香族氨基酸）的血浆浓度与多种疾病之间的关联。方1488 科目。参与者的信息与电子健康记录相关联。慢性病被归类为 60 种相互排斥的疾病。多重发病率的定量测量，通过其对身体机能的回归系数对发病率进行加权，被雇用，范围从 0 到 100。广义估计方程模型被用来探索血浆氨基酸和多发病之间的关系，调整社会人口统计学、社会经济地位和生活方式行为。结果参与者的基线平均年龄为 73.6 (SD = 4.2) 岁，其中 49.6% 为女性。更高浓度的谷氨酰胺[系数。每 mmol/l（95% 置信区间 = 10.1 (3.7, 16.6)）、异亮氨酸 [50.3 (21.7, 78.9)] 和缬氨酸 [15.5 (3.1, 28.0)] 在针对潜在混杂因素进行调整后与较高的多病评分显着相关. 体重指数可能影响异亮氨酸与多病症之间的关系 (p = 0.016) 结论 氨基酸可在调节与衰老相关的疾病中发挥作用。