The replication of human cytomegalovirus (HCMV) requires a metal-dependent endonuclease at the C-terminus of pUL89 (pUL89-C), which bears an RNase H / integrase-like active site, structurally and catalytically. We report herein the synthesis and biochemical, antiviral, biophysical and in silico characterization of a few metal-binding 8-hydroxy-1,6-naphthyridine subtypes. Synthesized analogs feature structural variations at R¹ and R².

中文翻译：

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8-Hydroxy-1,6-naphthyridine-7-carboxamides 作为人类巨细胞病毒 pUL89 核酸内切酶的抑制剂

人巨细胞病毒 (HCMV)的复制需要在 pUL89 (pUL89-C) 的 C 端具有金属依赖性内切酶，该酶在结构和催化上具有 RNase H / 整合酶样活性位点。我们在此报告了一些金属结合的 8-羟基-1,6-萘啶亚型的合成和生化、抗病毒、生物物理和计算机表征。合成的类似物在 R ¹和 R ²处具有结构变化。