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Factors Associated With In-Hospital Post–Cardiac Arrest Survival in a Referral Level Hospital in Uganda
Anesthesia & Analgesia ( IF 4.6 ) Pub Date : 2022-07-25 , DOI: 10.1213/ane.0000000000006132
Rachel Aguma Alum 1 , Joseph Kyobe Kiwanuka 1 , Doreen Nakku 2 , Elijah Ronald Kakande 3 , Victoria Nyaiteera 1 , Stephen Senyonjo Ttendo 1
Affiliation  

rvival after CA and associated factors in low-resource settings such as East Africa where Uganda is located. This study set out to describe post-CA survival, associated factors, and neurological outcome at a hospital in Southwestern Uganda. METHODS: This was a descriptive study in which we followed up with resuscitated CA patients from any of the selected hospital locations at Mbarara Regional Referral Hospital in Southwestern Uganda. We included all patients who were resuscitated after an index CA in the operating room (OR), intensive care unit (ICU), the pediatric ward, or accident and emergency (A&E) wards. Details of resuscitation were obtained from resuscitation team leader interviews and patient medical records. We followed up with patients with return of spontaneous circulation (ROSC) for up to 7 days after CA when neurological outcomes were measured using the age-appropriate Cerebral Performance Category (CPC) score. Factors affecting survival were then determined. RESULTS: A total of 74 participants were enrolled over 8 months. Seven-day survival was 14.86%. Eight of the 11 survivors had a CPC score of 1 seven days after CA. Admission with trauma was associated with increased mortality with an adjusted hazard ratio (HR) of 4.06; 95% confidence interval (CI), 1.19–13.82. Compared to the A&E ward, HR for index CA in OR, ICU, and pediatric ward was 0.15; 95% CI, 0.05–0.45; 0.67; 95% CI, 0.32–1.40, and 0.65; 95% CI, 0.25–1.69, respectively. Compared to cardiopulmonary resuscitation (CPR) <10 minutes, the HR for CPR duration between 10 and 20 minutes was 2.26; 95% CI, 0.78–3.24 and for >20 minutes was 2.26; 95% CI, 1.12–4.56. Prevention of hypotension after ROSC was associated with decreased mortality with an HR of 0.23; 95% CI, 0.08–0.58. CONCLUSIONS: Whereas 7-day survival of resuscitated CA patients at Mbarara Regional Referral Hospital (MRRH) was low, survivors had a good neurologic outcome. CA in the OR, CPR <20 minutes, and prevention of hypotension postarrest seemed to be associated with survival....

中文翻译:

与乌干达转诊医院心脏骤停后院内存活率相关的因素

CA 后的 rvival 和相关因素在资源匮乏的环境中,例如乌干达所在的东非。本研究旨在描述乌干达西南部一家医院的 CA 后存活率、相关因素和神经系统结果。方法:这是一项描述性研究,我们对来自乌干达西南部姆巴拉拉地区转诊医院的任何选定医院地点的复苏 CA 患者进行了随访。我们纳入了在手术室 (OR)、重症监护病房 (ICU)、儿科病房或急症室 (A&E) 病房进行指数 CA 后复苏的所有患者。复苏的细节是从复苏小组组长的访谈和病人的医疗记录中获得的。我们对 CA 后恢复自主循环 (ROSC) 的患者进行了长达 7 天的随访,当时使用适合年龄的脑功能类别 (CPC) 评分测量了神经学结果。然后确定影响存活的因素。结果:在 8 个月的时间里,共有 74 名参与者入组。7 天生存率为 14.86%。CA 7 天后,11 名幸存者中有 8 名的 CPC 得分为 1。因创伤入院与死亡率增加相关,调整后的风险比 (HR) 为 4.06;95% 置信区间 (CI),1.19–13.82。与 A&E 病房相比,OR、ICU 和儿科病房的指数 CA HR 为 0.15;95% 置信区间,0.05–0.45;0.67;95% CI,0.32–1.40 和 0.65;95% CI,分别为 0.25–1.69。与心肺复苏 (CPR) <10 分钟相比,CPR 持续时间在 10 到 20 分钟之间的 HR 为 2.26;95% CI,0.78–3.24,>20 分钟为 2.26;95% 置信区间,1.12–4.56。ROSC 后预防低血压与死亡率降低相关,HR 为 0.23;95% 置信区间,0.08–0.58。结论:虽然姆巴拉拉地区转诊医院 (MRRH) 复苏的 CA 患者的 7 天生存率很低,但幸存者的神经系统结果良好。手术室中的 CA、CPR <20 分钟和预防低血压似乎与生存有关…… 幸存者有良好的神经系统结果。手术室中的 CA、CPR <20 分钟和预防低血压似乎与生存有关…… 幸存者有良好的神经系统结果。手术室中的 CA、CPR <20 分钟和预防低血压似乎与生存有关……
更新日期:2022-07-25
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