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Lanthanide/Cu2–xSe Nanoparticles for Bacteria-Activated NIR-II Fluorescence Imaging of Infection
ACS Sensors ( IF 8.2 ) Pub Date : 2022-07-25 , DOI: 10.1021/acssensors.2c00683 Leilei Sun 1 , Sisi Shi 1 , Zeming Wu 2 , Yao Huang 1 , Chenhui Ji 1 , Craig A Grimes 3 , Xinxin Feng 1 , Qingyun Cai 1
ACS Sensors ( IF 8.2 ) Pub Date : 2022-07-25 , DOI: 10.1021/acssensors.2c00683 Leilei Sun 1 , Sisi Shi 1 , Zeming Wu 2 , Yao Huang 1 , Chenhui Ji 1 , Craig A Grimes 3 , Xinxin Feng 1 , Qingyun Cai 1
Affiliation
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A material system enabling specific NIR-II fluorescence imaging of Gram-positive bacteria is described. The material system is based on the electrostatic binding of Cu2–xSe and vancomycin-modified NaGdF4:Nd,Yb@NaGdF4 downconversion nanoparticles (DCNPs), the fluorescence of which is weak owing to the spectral overlap of Cu2–xSe absorption with the DCNP NIR emission. The presence of Gram-positive bacteria precisely disconnects the bond between vancomycin-modified DCNPs and Cu2–xSe, thus enabling a strong fluorescent signal. In vivo studies show that the material system can be specifically activated at the site of Gram-positive bacterial infection but is essentially nonfluorescent in the area of Gram-negative bacterial infection.
中文翻译：
用于感染的细菌激活 NIR-II 荧光成像的镧系元素/Cu2-xSe 纳米粒子
描述了一种能够对革兰氏阳性菌进行特定 NIR-II 荧光成像的材料系统。该材料系统基于 Cu 2– x Se 和万古霉素修饰的 NaGdF 4 :Nd,Yb@NaGdF 4下转换纳米粒子 (DCNP) 的静电结合，由于 Cu 2– x的光谱重叠，其荧光较弱Se 吸收与 DCNP NIR 发射。革兰氏阳性细菌的存在精确地断开了万古霉素修饰的 DCNP 与 Cu 2– x Se 之间的结合，从而产生了强烈的荧光信号。体内研究表明，材料系统可以在革兰氏阳性细菌感染部位被特异性激活，但在革兰氏阴性细菌感染区域基本上不发荧光。
更新日期：2022-07-25
中文翻译：
用于感染的细菌激活 NIR-II 荧光成像的镧系元素/Cu2-xSe 纳米粒子
描述了一种能够对革兰氏阳性菌进行特定 NIR-II 荧光成像的材料系统。该材料系统基于 Cu 2– x Se 和万古霉素修饰的 NaGdF 4 :Nd,Yb@NaGdF 4下转换纳米粒子 (DCNP) 的静电结合，由于 Cu 2– x的光谱重叠，其荧光较弱Se 吸收与 DCNP NIR 发射。革兰氏阳性细菌的存在精确地断开了万古霉素修饰的 DCNP 与 Cu 2– x Se 之间的结合，从而产生了强烈的荧光信号。体内研究表明，材料系统可以在革兰氏阳性细菌感染部位被特异性激活，但在革兰氏阴性细菌感染区域基本上不发荧光。
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