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Blood-based bioenergetic profiling reveals differences in mitochondrial function associated with cognitive performance and Alzheimer's disease
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2022-07-23 , DOI: 10.1002/alz.12731
Gargi Mahapatra 1 , Zhengrong Gao 1 , James R Bateman 1, 2 , Samuel Neal Lockhart 1 , Jaclyn Bergstrom 3 , Amber Renee DeWitt 1 , Jemima Elizabeth Piloso 1 , Philip Adam Kramer 1 , Jenny L Gonzalez-Armenta 1 , Kimberly Allison Amick 1 , Ramon Casanova 4 , Suzanne Craft 1 , Anthony J A Molina 3
Affiliation  

Despite evidence for systemic mitochondrial dysfunction early in Alzheimer's disease (AD) pathogenesis, reliable approaches monitoring these key bioenergetic alterations are lacking. We used peripheral blood mononuclear cells (PBMCs) and platelets as reporters of mitochondrial function in the context of cognitive impairment and AD.

中文翻译:


基于血液的生物能量分析揭示了与认知表现和阿尔茨海默病相关的线粒体功能差异



尽管有证据表明阿尔茨海默病(AD)发病早期存在系统性线粒体功能障碍,但仍缺乏监测这些关键生物能变化的可靠方法。我们使用外周血单核细胞 (PBMC) 和血小板作为认知障碍和 AD 背景下线粒体功能的报告者。
更新日期:2022-07-23
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