Palladium(II)-catalyzed enantioselective intermolecular oxidative diarylation of internal enamides,Chemical Communications

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Palladium(II)-catalyzed enantioselective intermolecular oxidative diarylation of internal enamides
Chemical Communications ( IF 4.3 ) Pub Date : 2022-07-25 , DOI: 10.1039/d2cc03202c
Tingting Xia ₁ , Yang Xi ₁ , Haojie Ding ₁ , Yetong Zhang ₁ , Ke Fang ₁ , Xianqing Wu ₁ , Jingping Qu ₁ , Yifeng Chen ₁

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The construction of vicinal stereogenic centers via the simultaneous formation of two C–C bonds across alkenes under oxidative conditions is a stubborn challenge. Herein, we report a Pd(II)-catalyzed highly enantioselective intermolecular oxidative 1,2-diarylation reaction of internal enamides with aryl boronic acids, enabling the expedient construction of two vicinal stereocenters with excellent diastereo-, and enantioselectivities.

中文翻译：

钯 (II) 催化的内部烯酰胺的对映选择性分子间氧化二芳基化

通过在氧化条件下在烯烃上同时形成两个 C-C 键来构建邻位立体中心是一个顽固的挑战。在此，我们报告了 Pd( II ) 催化的内烯酰胺与芳基硼酸的高度对映选择性分子间氧化 1,2-二芳基化反应，从而能够方便地构建两个具有优异非对映选择性和对映选择性的邻位立体中心。

更新日期：2022-07-29

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