Abstract

Ischemic stroke (IS) is a global health challenge leading to life-long disabilities or the deaths of patients. IS is a complex disease where genetic and environmental factors are both concerned with the pathophysiology of the condition. Here, we aimed to investigate various microRNA (miRNA) expressions and their targets in IS. A rapid and accurate diagnosis of acute IS is important to perform appropriate treatment. Therefore, there is a need for a more rapid and simple tool to carry out an acute diagnosis of IS. miRNAs are small RNA molecules serving as precious biomarkers due to their easy detection and stability in blood samples. The present systematic review aimed to summarize previous studies investigating several miRNA expressions and their targets in IS.

摘要

缺血性中风 (IS) 是一项全球性的健康挑战，会导致终生残疾或患者死亡。IS 是一种复杂的疾病，其中遗传和环境因素都与疾病的病理生理学有关。在这里，我们旨在研究 IS 中的各种 microRNA (miRNA) 表达及其靶标。急性 IS 的快速准确诊断对于进行适当的治疗很重要。因此，需要一种更快速、更简单的工具来进行 IS 的急性诊断。miRNA 是一种小 RNA 分子，因其在血液样本中易于检测和稳定性而成为宝贵的生物标志物。本系统综述旨在总结以前研究 IS 中几种 miRNA 表达及其靶标的研究。