Objective To assess the longitudinal changes in nailfold videocapillaroscopy (NVC) in patients expressing myositis-specific autoantibodies (anti-aminoacyl-tRNA synthetase [ARS], anti-transcriptional intermediary factor 1 [TIF1], and anti-melanoma differentiation-associated gene 5 [MDA5]). Methods This study was performed retrospectively, at a single site, on an observational cohort. Seventy-one idiopathic inflammatory myopathy patients were included (25 patients expressed anti-MDA5 Abs, 24 patients expressed anti-TIF1 Abs, and 22 patients expressed anti-ARS Abs). NVC findings included giant, enlarged, and reduced capillaries, hemorrhages, capillary ramification, disorganization of the vascular array, and capillary loss. NVC findings were compared from baseline to after disease activity stabilization. Results The frequency of enlarged capillaries at baseline was different among the three groups, and was significantly higher in patients with anti-TIF1 Abs compared with those with anti-ARS Abs (88% vs 55%, p< 0.05). Reduced capillaries were significantly increased in patients with anti-TIF1 Abs compared with those with anti-MDA5 (96% vs 44%, p< 0.0001) or anti-ARS Abs (96% vs 50%, p< 0.0005). Both enlarged and reduced capillaries improved after stabilization in patients with anti-MDA5 Abs (p< 0.0001 and p< 0.05, respectively). These improvements were not observed in patients expressing anti-TIF1 and anti-ARS Abs. However, a significant reduction in hemorrhages was observed in all three groups (p< 0.0001 for each group). Conclusions The results of this study demonstrate that longitudinal changes in NVC findings may vary depending on myositis-specific Ab expression. Therefore, it is crucial to assess individual NVC findings separately, since each finding may impact disease activity in a different manner.

中文翻译：

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特发性炎症性肌病中甲襞视频毛细血管镜检查结果的纵向变化因肌炎特异性自身抗体而异

目的 评估表达肌炎特异性自身抗体（抗氨酰 tRNA 合成酶 [ARS]、抗转录中介因子 1 [TIF1] 和抗黑色素瘤分化相关基因 5）患者甲襞视频毛细血管镜检查 (NVC) 的纵向变化 [ MDA5]). 方法 本研究是在一个观察点对一个观察队列进行回顾性研究。包括 71 名特发性炎症性肌病患者（25 名患者表达抗 MDA5 抗体，24 名患者表达抗 TIF1 抗体，22 名患者表达抗 ARS 抗体）。NVC 结果包括巨大的、扩大的和缩小的毛细血管、出血、毛细血管分支、血管阵列的解体和毛细血管丢失。将 NVC 结果从基线到疾病活动稳定后进行比较。结果 三组患者基线时毛细血管扩张的频率不同，抗 TIF1 抗体患者显着高于抗 ARS 抗体患者（88% 对 55%，p < 0.05）。与抗 MDA5 (96% vs 44%, p<0.0001) 或抗 ARS Abs (96% vs 50%, p<0.0005) 患者相比，抗 TIF1 抗体患者减少的毛细血管显着增加。抗 MDA5 抗体稳定后，扩大和缩小的毛细血管均得到改善（分别为 p < 0.0001 和 p < 0.05）。在表达抗 TIF1 和抗 ARS 抗体的患者中未观察到这些改善。然而，在所有三组中均观察到出血显着减少(每组p＜0.0001)。结论 本研究的结果表明，NVC 结果的纵向变化可能因肌炎特异性 Ab 表达而异。因此，单独评估单个 NVC 结果至关重要，因为每个结果都可能以不同的方式影响疾病活动。